Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types
Cancer is a life-threatening concern worldwide. Sensitive and early-stage diagnostics of different cancer types can make it possible for patients to get through the best available treatment options to combat this menace. Among several new detection methods, aptamer-based biosensors (aptasensors) hav...
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doaj-ed9cf72ea159477c8cf754927662d9bc2021-02-25T04:55:42ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011110.3389/fonc.2021.632165632165Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer TypesQurat ul ain Zahra0Qurat ul ain Zahra1Qaiser Ali Khan2Zhaofeng Luo3Core Facility Center for Life Sciences, Department of Biochemistry and Molecular Biology, School of Life Sciences, University of Sciences and Technology of China, Hefei, ChinaHefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, ChinaInstitute of Chemistry of New Materials, Universität Osnabrück, Osnabrück, GermanyCore Facility Center for Life Sciences, Department of Biochemistry and Molecular Biology, School of Life Sciences, University of Sciences and Technology of China, Hefei, ChinaCancer is a life-threatening concern worldwide. Sensitive and early-stage diagnostics of different cancer types can make it possible for patients to get through the best available treatment options to combat this menace. Among several new detection methods, aptamer-based biosensors (aptasensors) have recently shown promising results in terms of sensitivity, identification, or detection of either cancerous cells or the associated biomarkers. In this mini-review, we have summarized the most recent (2016–2020) developments in different approaches belonging to optical aptasensor technologies being widely employed for their simple operation, sensitivity, and early cancer diagnostics. Finally, we shed some light on limitations, advantages, and current challenges of aptasensors in clinical diagnostics, and we elaborated on some future perspectives.https://www.frontiersin.org/articles/10.3389/fonc.2021.632165/fulloptical aptasensorsearly cancer diagnosticscancer biomarkersfluorescence aptasensorschemiluminescenceSERS cancer aptasensors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qurat ul ain Zahra Qurat ul ain Zahra Qaiser Ali Khan Zhaofeng Luo |
spellingShingle |
Qurat ul ain Zahra Qurat ul ain Zahra Qaiser Ali Khan Zhaofeng Luo Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types Frontiers in Oncology optical aptasensors early cancer diagnostics cancer biomarkers fluorescence aptasensors chemiluminescence SERS cancer aptasensors |
author_facet |
Qurat ul ain Zahra Qurat ul ain Zahra Qaiser Ali Khan Zhaofeng Luo |
author_sort |
Qurat ul ain Zahra |
title |
Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types |
title_short |
Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types |
title_full |
Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types |
title_fullStr |
Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types |
title_full_unstemmed |
Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types |
title_sort |
advances in optical aptasensors for early detection and diagnosis of various cancer types |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-02-01 |
description |
Cancer is a life-threatening concern worldwide. Sensitive and early-stage diagnostics of different cancer types can make it possible for patients to get through the best available treatment options to combat this menace. Among several new detection methods, aptamer-based biosensors (aptasensors) have recently shown promising results in terms of sensitivity, identification, or detection of either cancerous cells or the associated biomarkers. In this mini-review, we have summarized the most recent (2016–2020) developments in different approaches belonging to optical aptasensor technologies being widely employed for their simple operation, sensitivity, and early cancer diagnostics. Finally, we shed some light on limitations, advantages, and current challenges of aptasensors in clinical diagnostics, and we elaborated on some future perspectives. |
topic |
optical aptasensors early cancer diagnostics cancer biomarkers fluorescence aptasensors chemiluminescence SERS cancer aptasensors |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.632165/full |
work_keys_str_mv |
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