The Cbs Locus Affects the Expression of Senescence Markers and mtDNA Copy Number, but not Telomere Dynamics in Mice

The Cbs Locus Affects the Expression of Senescence Markers and mtDNA Copy Number, but not Telomere Dynamics in Mice

Cystathionine β-synthase (CBS) is a housekeeping enzyme that catalyzes the first step of the homocysteine to cysteine transsulfuration pathway. Homozygous deletion of the <i>Cbs</i> gene in mice causes severe hyperhomocysteinemia and reduces life span. Here, we examined a possible involv...

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Bibliographic Details
Main Authors: Olga Utyro, Joanna Perła-Kaján, Hieronim Jakubowski
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
cystathionine β-synthase deficiency
homocysteine
life span
mtDNA
senescence markers
telomere dynamics
Online Access:https://www.mdpi.com/1422-0067/21/7/2520

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