The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging

The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging

An increased accumulation of immune-dysfunction-associated CD4+Foxp3+ regulatory T cells (Tregs) is observed in aging oral mucosa during infection. Here we studied the function of Tregs during oral cancer development in aging mucosa. First, we found heightened proportions of Tregs and myeloid-derive...

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Bibliographic Details
Main Authors: Natarajan Bhaskaran, Sangeetha Jayaraman, Cheriese Quigley, Prerna Mamileti, Mahmoud Ghannoum, Aaron Weinberg, Jason Thuener, Quintin Pan, Pushpa Pandiyan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
Treg
Foxp3
Treg17
IL-1β
Candida
oral cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.669066/full

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