Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell Carcinoma
Objective To observe the expression of microRNA(miRNA, miR)-181d in esophageal squamous cell carcinoma (ESCC) tissues and to explore its clinical significance. Methods Reverse transcription quantitative real-time PCR(RT-qPCR) was used to detect the miR-181d expression in 37 cases of ESCC tissues and...
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Magazine House of Cancer Research on Prevention and Treatment
2018-12-01
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doaj-edac07af555b4851b9831e5b7966237b2020-11-25T02:10:43ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782018-12-01451298198410.3971/j.issn.1000-8578.2018.18.07168578.2018.18.0716Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell CarcinomaGONG Fenfen0HAN Pengli1CUI Yuanbo2CAO Xinguang3ZHAO Ruihua4ZHAN Xiang5LI Xuemin6CAO Wei7Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, ChinaTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, ChinaTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, ChinaDepartment of Endoscopy Surgery, He'nan Cancer Hospital Affiliated to Zhengzhou University, Zhengzhou 450008, ChinaDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, ChinaTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, ChinaTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, ChinaObjective To observe the expression of microRNA(miRNA, miR)-181d in esophageal squamous cell carcinoma (ESCC) tissues and to explore its clinical significance. Methods Reverse transcription quantitative real-time PCR(RT-qPCR) was used to detect the miR-181d expression in 37 cases of ESCC tissues and matched adjacent tissues. The correlations of miR-181d expression with clinicpathological features and clinical prognosis were analyzed. Results miR-181d expression was up-regulated in 89.2%(33/37) of ESCC tissues, compared with the matched adjacent tissues (P < 0.01). The expression level of miR-181d was not significantly correlated with gender, age, depth of invasion, lymph node metastasis, histological grade or tumor location(P > 0.05), but significantly related to TNM staging (P < 0.05). Kaplan-Meier survival analysis showed that the overall survival rate and the disease-free survival rate of the high miR-181d expression group was significantly lower than that of the low miR-181d expression group (P < 0.05). Conclusion miR-181d expression is related to TNM and prognosis of ESCC patients. miR-181d may be used as a potential predictor to evaluate the prognosis of ESCC patients.http://html.rhhz.net/ZLFZYJ/html/8578.2018.18.0716.htmesophageal squamous cell carcinomamir-181dprognosis |
collection |
DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
GONG Fenfen HAN Pengli CUI Yuanbo CAO Xinguang ZHAO Ruihua ZHAN Xiang LI Xuemin CAO Wei |
spellingShingle |
GONG Fenfen HAN Pengli CUI Yuanbo CAO Xinguang ZHAO Ruihua ZHAN Xiang LI Xuemin CAO Wei Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell Carcinoma Zhongliu Fangzhi Yanjiu esophageal squamous cell carcinoma mir-181d prognosis |
author_facet |
GONG Fenfen HAN Pengli CUI Yuanbo CAO Xinguang ZHAO Ruihua ZHAN Xiang LI Xuemin CAO Wei |
author_sort |
GONG Fenfen |
title |
Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell Carcinoma |
title_short |
Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell Carcinoma |
title_full |
Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell Carcinoma |
title_fullStr |
Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell Carcinoma |
title_full_unstemmed |
Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell Carcinoma |
title_sort |
expression and clinical significance of mirna-181d in esophageal squamous cell carcinoma |
publisher |
Magazine House of Cancer Research on Prevention and Treatment |
series |
Zhongliu Fangzhi Yanjiu |
issn |
1000-8578 1000-8578 |
publishDate |
2018-12-01 |
description |
Objective To observe the expression of microRNA(miRNA, miR)-181d in esophageal squamous cell carcinoma (ESCC) tissues and to explore its clinical significance. Methods Reverse transcription quantitative real-time PCR(RT-qPCR) was used to detect the miR-181d expression in 37 cases of ESCC tissues and matched adjacent tissues. The correlations of miR-181d expression with clinicpathological features and clinical prognosis were analyzed. Results miR-181d expression was up-regulated in 89.2%(33/37) of ESCC tissues, compared with the matched adjacent tissues (P < 0.01). The expression level of miR-181d was not significantly correlated with gender, age, depth of invasion, lymph node metastasis, histological grade or tumor location(P > 0.05), but significantly related to TNM staging (P < 0.05). Kaplan-Meier survival analysis showed that the overall survival rate and the disease-free survival rate of the high miR-181d expression group was significantly lower than that of the low miR-181d expression group (P < 0.05). Conclusion miR-181d expression is related to TNM and prognosis of ESCC patients. miR-181d may be used as a potential predictor to evaluate the prognosis of ESCC patients. |
topic |
esophageal squamous cell carcinoma mir-181d prognosis |
url |
http://html.rhhz.net/ZLFZYJ/html/8578.2018.18.0716.htm |
work_keys_str_mv |
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