Increasing the activity of DNAzyme based on the telomeric sequence: 2’-OMe-RNA and LNA modifications

2’-OMe-RNA analogues and LNA point modifications of DNA oligonucleotides were applied for the modulation of the G-quadruplex topology and enhancement of peroxidase activity of the resulting DNAzymes. The effect of the 2’-OMe-RNA analogue was studied for full length modified oligonucleotides with var...

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Bibliographic Details
Main Authors: Kosman J., Żukowski K., Juskowiak B.
Format: Article
Language:English
Published: De Gruyter 2019-12-01
Series:Open Chemistry
Subjects:
Online Access:https://doi.org/10.1515/chem-2019-0127

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