The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review
Abstract Background This systematic review aims to study the effectiveness of 5‐fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair. Method A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Leve...
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doaj-edb088f3070c413e8017a6c8b5183c522021-05-02T17:56:15ZengWileyAnimal Models and Experimental Medicine2576-20952020-03-0131879210.1002/ame2.12110The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic reviewOmid Nazifi0Andrew L. Stuart1Dariush Nikkhah2Royal Perth Hospital Perth WA AustraliaRoyal Perth Hospital Perth WA AustraliaLocum Consultant Plastic Surgeon Department of Plastic and Reconstructive Surgery Royal Free London NHS Foundation Trust London UKAbstract Background This systematic review aims to study the effectiveness of 5‐fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair. Method A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or Level II (according to NHMRC) in the use of 5FU in tendon repairs in human or animal studies. Results Across the four databases 546 articles were identified. Of these 12 were identified as relevant, with a further two being excluded after in depth review. Conclusions Nine of the 10 studies showed that 5FU was effective at reducing tendon adhesions in their respective animal studies. One of the 10 studies showed no significant change compared to the control group.https://doi.org/10.1002/ame2.121105FUanimal modelsphysiologyplasticstendon |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Omid Nazifi Andrew L. Stuart Dariush Nikkhah |
spellingShingle |
Omid Nazifi Andrew L. Stuart Dariush Nikkhah The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review Animal Models and Experimental Medicine 5FU animal models physiology plastics tendon |
author_facet |
Omid Nazifi Andrew L. Stuart Dariush Nikkhah |
author_sort |
Omid Nazifi |
title |
The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review |
title_short |
The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review |
title_full |
The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review |
title_fullStr |
The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review |
title_full_unstemmed |
The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review |
title_sort |
use of 5‐fluorouracil in the prevention of tendon adhesions: a systematic review |
publisher |
Wiley |
series |
Animal Models and Experimental Medicine |
issn |
2576-2095 |
publishDate |
2020-03-01 |
description |
Abstract Background This systematic review aims to study the effectiveness of 5‐fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair. Method A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or Level II (according to NHMRC) in the use of 5FU in tendon repairs in human or animal studies. Results Across the four databases 546 articles were identified. Of these 12 were identified as relevant, with a further two being excluded after in depth review. Conclusions Nine of the 10 studies showed that 5FU was effective at reducing tendon adhesions in their respective animal studies. One of the 10 studies showed no significant change compared to the control group. |
topic |
5FU animal models physiology plastics tendon |
url |
https://doi.org/10.1002/ame2.12110 |
work_keys_str_mv |
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