Rapid detection and monitoring of human coronavirus infections

Rapid detection and monitoring of human coronavirus infections

Human coronaviruses (CoVs) are increasingly recognized as important respiratory pathogens associated with a broad range of clinical diseases. We sought to increase the insight into clinically relevant CoV infections by monitoring antigen concentrations in six confirmed CoV-positive patients using a...

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Main Authors: A.H.L. Bruning, H. Aatola, H. Toivola, N. Ikonen, C. Savolainen-Kopra, S. Blomqvist, D. Pajkrt, K.C. Wolthers, J.O. Koskinen
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:New Microbes and New Infections
Online Access:http://www.sciencedirect.com/science/article/pii/S2052297518300350
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spelling doaj-edb97cd248a94aa4a2db1666eb9ec9602020-11-25T01:44:32ZengElsevierNew Microbes and New Infections2052-29752018-07-01245255Rapid detection and monitoring of human coronavirus infectionsA.H.L. Bruning0H. Aatola1H. Toivola2N. Ikonen3C. Savolainen-Kopra4S. Blomqvist5D. Pajkrt6K.C. Wolthers7J.O. Koskinen8Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands; Corresponding author: A. H. L. Bruning, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ArcDia International Oy Ltd, Turku, FinlandArcDia International Oy Ltd, Turku, FinlandNational Institute for Health and Welfare (THL), Helsinki, FinlandNational Institute for Health and Welfare (THL), Helsinki, FinlandNational Institute for Health and Welfare (THL), Helsinki, FinlandDepartment of Pediatric Infectious Diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The NetherlandsArcDia International Oy Ltd, Turku, FinlandHuman coronaviruses (CoVs) are increasingly recognized as important respiratory pathogens associated with a broad range of clinical diseases. We sought to increase the insight into clinically relevant CoV infections by monitoring antigen concentrations in six confirmed CoV-positive patients using a newly developed assay for rapid detection of CoV OC43 infections. Antigen positivity lasted 3 to 6 days in secondary infections and 13 days in primary infection. CoV infections are clinically diverse, are common, and cannot be diagnosed from clinical symptoms alone. Keywords: Human coronavirus, point-of-care test, rapid antigen test, rapid detection, respiratory tract infectionhttp://www.sciencedirect.com/science/article/pii/S2052297518300350
collection DOAJ
language English
format Article
sources DOAJ
author A.H.L. Bruning
H. Aatola
H. Toivola
N. Ikonen
C. Savolainen-Kopra
S. Blomqvist
D. Pajkrt
K.C. Wolthers
J.O. Koskinen
spellingShingle A.H.L. Bruning
H. Aatola
H. Toivola
N. Ikonen
C. Savolainen-Kopra
S. Blomqvist
D. Pajkrt
K.C. Wolthers
J.O. Koskinen
Rapid detection and monitoring of human coronavirus infections
New Microbes and New Infections
author_facet A.H.L. Bruning
H. Aatola
H. Toivola
N. Ikonen
C. Savolainen-Kopra
S. Blomqvist
D. Pajkrt
K.C. Wolthers
J.O. Koskinen
author_sort A.H.L. Bruning
title Rapid detection and monitoring of human coronavirus infections
title_short Rapid detection and monitoring of human coronavirus infections
title_full Rapid detection and monitoring of human coronavirus infections
title_fullStr Rapid detection and monitoring of human coronavirus infections
title_full_unstemmed Rapid detection and monitoring of human coronavirus infections
title_sort rapid detection and monitoring of human coronavirus infections
publisher Elsevier
series New Microbes and New Infections
issn 2052-2975
publishDate 2018-07-01
description Human coronaviruses (CoVs) are increasingly recognized as important respiratory pathogens associated with a broad range of clinical diseases. We sought to increase the insight into clinically relevant CoV infections by monitoring antigen concentrations in six confirmed CoV-positive patients using a newly developed assay for rapid detection of CoV OC43 infections. Antigen positivity lasted 3 to 6 days in secondary infections and 13 days in primary infection. CoV infections are clinically diverse, are common, and cannot be diagnosed from clinical symptoms alone. Keywords: Human coronavirus, point-of-care test, rapid antigen test, rapid detection, respiratory tract infection
url http://www.sciencedirect.com/science/article/pii/S2052297518300350
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