Malaria vaccines: lessons from field trials
Malaria vaccine candidates have already been tested and new trials are being carried out. We present a brief description of specific issues of validity that are relevant when assessing vaccine efficacy in the field and illustrate how the application of these principles might improve our interpretati...
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Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
1994-07-01
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Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1994000800009&lng=en&tlng=en |
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doaj-edbc137724cb480fb7e3bc60bae75f982020-11-25T04:04:03ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-44641994-07-0110suppl 2S310S326S0102-311X1994000800009Malaria vaccines: lessons from field trialsClaudio J. Struchiner0M. Elizabeth Halloran1Robert C. Brunet2José M. C. Ribeiro3Eduardo Massad4Fundação Oswaldo CruzEmory University School of Public HealthUniversité de MontréalUniversity of ArizonaUniversidade de São PauloMalaria vaccine candidates have already been tested and new trials are being carried out. We present a brief description of specific issues of validity that are relevant when assessing vaccine efficacy in the field and illustrate how the application of these principles might improve our interpretation of the data being gathered in actual malaria vaccine field trials. Our discussion assumes that vaccine evaluation shares the same general principles of validity with epidemiologic causal inference, i.e., the process of drawing inferences from epidemiologic data aiming at the identification of causes of diseases. Judicious exercise of these principles indicates that, for meaningful interpretation, measures of vaccine efficacy require definitions based upon arguments conditional on the amount of exposure to infection, and specification of the initial and final states in which one believes the effect of interest takes place.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1994000800009&lng=en&tlng=enmalariavaccinevaccine efficacyfield trial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudio J. Struchiner M. Elizabeth Halloran Robert C. Brunet José M. C. Ribeiro Eduardo Massad |
spellingShingle |
Claudio J. Struchiner M. Elizabeth Halloran Robert C. Brunet José M. C. Ribeiro Eduardo Massad Malaria vaccines: lessons from field trials Cadernos de Saúde Pública malaria vaccine vaccine efficacy field trial |
author_facet |
Claudio J. Struchiner M. Elizabeth Halloran Robert C. Brunet José M. C. Ribeiro Eduardo Massad |
author_sort |
Claudio J. Struchiner |
title |
Malaria vaccines: lessons from field trials |
title_short |
Malaria vaccines: lessons from field trials |
title_full |
Malaria vaccines: lessons from field trials |
title_fullStr |
Malaria vaccines: lessons from field trials |
title_full_unstemmed |
Malaria vaccines: lessons from field trials |
title_sort |
malaria vaccines: lessons from field trials |
publisher |
Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
series |
Cadernos de Saúde Pública |
issn |
0102-311X 1678-4464 |
publishDate |
1994-07-01 |
description |
Malaria vaccine candidates have already been tested and new trials are being carried out. We present a brief description of specific issues of validity that are relevant when assessing vaccine efficacy in the field and illustrate how the application of these principles might improve our interpretation of the data being gathered in actual malaria vaccine field trials. Our discussion assumes that vaccine evaluation shares the same general principles of validity with epidemiologic causal inference, i.e., the process of drawing inferences from epidemiologic data aiming at the identification of causes of diseases. Judicious exercise of these principles indicates that, for meaningful interpretation, measures of vaccine efficacy require definitions based upon arguments conditional on the amount of exposure to infection, and specification of the initial and final states in which one believes the effect of interest takes place. |
topic |
malaria vaccine vaccine efficacy field trial |
url |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1994000800009&lng=en&tlng=en |
work_keys_str_mv |
AT claudiojstruchiner malariavaccineslessonsfromfieldtrials AT melizabethhalloran malariavaccineslessonsfromfieldtrials AT robertcbrunet malariavaccineslessonsfromfieldtrials AT josemcribeiro malariavaccineslessonsfromfieldtrials AT eduardomassad malariavaccineslessonsfromfieldtrials |
_version_ |
1724437960373305344 |