Nasal Mucosal Melanosis may act as a Harbinger of Melanoma: A Case Report
Background The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma ove...
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doaj-edc0c4959dcf4544a45d1b595190b07d2020-11-25T02:59:17ZengSAGE PublishingAllergy & Rhinology2152-65672016-09-01710.2500/ar.2016.7.0174Nasal Mucosal Melanosis may act as a Harbinger of Melanoma: A Case ReportWilliam C. Yao M.D.0Kevin S. Emerick M.D.1Stefan Kraft M.D.2Eric H. Holbrook M.D.3Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MassachusettsDepartment of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MassachusettsDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MassachusettsDepartment of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MassachusettsBackground The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time. Objective To describe a transformation of a mucosal melanosis into melanoma. Methods A 53-year-old man with diffuse melanosis of the nasal cavity underwent surgical resection. Results Pathology revealed melanocytic hyperplasia without evidence of melanoma. The patient was serially examined, with excisions for new areas of melanosis. The pathology progressed to severely atypical melanocytic proliferation and melanoma in situ over a 4-year period. Conclusion Nasal melanosis may be a precancerous lesion and may transform into melanoma. All melanosis should be biopsied with close endoscopic observation. Lesions with dysplasia or atypia should be excised due to potential transformation to melanoma.https://doi.org/10.2500/ar.2016.7.0174 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
William C. Yao M.D. Kevin S. Emerick M.D. Stefan Kraft M.D. Eric H. Holbrook M.D. |
spellingShingle |
William C. Yao M.D. Kevin S. Emerick M.D. Stefan Kraft M.D. Eric H. Holbrook M.D. Nasal Mucosal Melanosis may act as a Harbinger of Melanoma: A Case Report Allergy & Rhinology |
author_facet |
William C. Yao M.D. Kevin S. Emerick M.D. Stefan Kraft M.D. Eric H. Holbrook M.D. |
author_sort |
William C. Yao M.D. |
title |
Nasal Mucosal Melanosis may act as a Harbinger of Melanoma: A Case Report |
title_short |
Nasal Mucosal Melanosis may act as a Harbinger of Melanoma: A Case Report |
title_full |
Nasal Mucosal Melanosis may act as a Harbinger of Melanoma: A Case Report |
title_fullStr |
Nasal Mucosal Melanosis may act as a Harbinger of Melanoma: A Case Report |
title_full_unstemmed |
Nasal Mucosal Melanosis may act as a Harbinger of Melanoma: A Case Report |
title_sort |
nasal mucosal melanosis may act as a harbinger of melanoma: a case report |
publisher |
SAGE Publishing |
series |
Allergy & Rhinology |
issn |
2152-6567 |
publishDate |
2016-09-01 |
description |
Background The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time. Objective To describe a transformation of a mucosal melanosis into melanoma. Methods A 53-year-old man with diffuse melanosis of the nasal cavity underwent surgical resection. Results Pathology revealed melanocytic hyperplasia without evidence of melanoma. The patient was serially examined, with excisions for new areas of melanosis. The pathology progressed to severely atypical melanocytic proliferation and melanoma in situ over a 4-year period. Conclusion Nasal melanosis may be a precancerous lesion and may transform into melanoma. All melanosis should be biopsied with close endoscopic observation. Lesions with dysplasia or atypia should be excised due to potential transformation to melanoma. |
url |
https://doi.org/10.2500/ar.2016.7.0174 |
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