The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes

This study explored the relationship between obstructive sleep apnea (OSA) and the presence of any diabetes-related complications in type 2 diabetes and whether this was mediated by hypertension. Secondly, the relationship between OSA severity and estimated glomerular filtration rate (eGFR) was inve...

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Main Authors: Nantaporn Siwasaranond, Hataikarn Nimitphong, Areesa Manodpitipong, Sunee Saetung, Naricha Chirakalwasan, Ammarin Thakkinstian, Sirimon Reutrakul
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2018/9269170
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spelling doaj-edc1d128bb994f2d8c6f7ed7ad35e9092020-11-24T20:47:32ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/92691709269170The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 DiabetesNantaporn Siwasaranond0Hataikarn Nimitphong1Areesa Manodpitipong2Sunee Saetung3Naricha Chirakalwasan4Ammarin Thakkinstian5Sirimon Reutrakul6Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, ThailandDivision of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, ThailandDivision of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, ThailandDivision of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, ThailandDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, ThailandDivision of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, ThailandThis study explored the relationship between obstructive sleep apnea (OSA) and the presence of any diabetes-related complications in type 2 diabetes and whether this was mediated by hypertension. Secondly, the relationship between OSA severity and estimated glomerular filtration rate (eGFR) was investigated. A total of 131 patients participated. OSA was diagnosed using a home monitor, and severity was measured by apnea-hypopnea index (AHI) and oxygen desaturation index (ODI). OSA was found in 75.6% of the participants, 40.5% with moderate-to-severe degree. Any diabetes-related complications (retinopathy, neuropathy, nephropathy, or coronary artery disease) were present in 55.5%, and 70.2% of the participants had hypertension. Mediation analysis indicated that, compared to those with mild or no OSA, those with moderate-to-severe OSA were 3.05 times more likely to have any diabetes-related complications and that this relationship was mediated by the presence of hypertension. After adjusting for confounders, ODI (B = −0.036, p=0.041), but not AHI, was significantly associated with lower eGFR. In conclusion, moderate-to-severe OSA was related to the presence of any diabetes-related complications in type 2 diabetes, and the relationship was mediated by hypertension. The severity of intermittent hypoxia was associated with lower eGFR. Whether OSA treatment will delay or reduce diabetes-related complications should be investigated.http://dx.doi.org/10.1155/2018/9269170
collection DOAJ
language English
format Article
sources DOAJ
author Nantaporn Siwasaranond
Hataikarn Nimitphong
Areesa Manodpitipong
Sunee Saetung
Naricha Chirakalwasan
Ammarin Thakkinstian
Sirimon Reutrakul
spellingShingle Nantaporn Siwasaranond
Hataikarn Nimitphong
Areesa Manodpitipong
Sunee Saetung
Naricha Chirakalwasan
Ammarin Thakkinstian
Sirimon Reutrakul
The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes
Journal of Diabetes Research
author_facet Nantaporn Siwasaranond
Hataikarn Nimitphong
Areesa Manodpitipong
Sunee Saetung
Naricha Chirakalwasan
Ammarin Thakkinstian
Sirimon Reutrakul
author_sort Nantaporn Siwasaranond
title The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes
title_short The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes
title_full The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes
title_fullStr The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes
title_full_unstemmed The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes
title_sort relationship between diabetes-related complications and obstructive sleep apnea in type 2 diabetes
publisher Hindawi Limited
series Journal of Diabetes Research
issn 2314-6745
2314-6753
publishDate 2018-01-01
description This study explored the relationship between obstructive sleep apnea (OSA) and the presence of any diabetes-related complications in type 2 diabetes and whether this was mediated by hypertension. Secondly, the relationship between OSA severity and estimated glomerular filtration rate (eGFR) was investigated. A total of 131 patients participated. OSA was diagnosed using a home monitor, and severity was measured by apnea-hypopnea index (AHI) and oxygen desaturation index (ODI). OSA was found in 75.6% of the participants, 40.5% with moderate-to-severe degree. Any diabetes-related complications (retinopathy, neuropathy, nephropathy, or coronary artery disease) were present in 55.5%, and 70.2% of the participants had hypertension. Mediation analysis indicated that, compared to those with mild or no OSA, those with moderate-to-severe OSA were 3.05 times more likely to have any diabetes-related complications and that this relationship was mediated by the presence of hypertension. After adjusting for confounders, ODI (B = −0.036, p=0.041), but not AHI, was significantly associated with lower eGFR. In conclusion, moderate-to-severe OSA was related to the presence of any diabetes-related complications in type 2 diabetes, and the relationship was mediated by hypertension. The severity of intermittent hypoxia was associated with lower eGFR. Whether OSA treatment will delay or reduce diabetes-related complications should be investigated.
url http://dx.doi.org/10.1155/2018/9269170
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