Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver
The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) as multifactorial chronic liver disease and the lack of a specific treatment have begun a new era in its treatment using gene expression changes and microRNAs. This study aimed to investigate the potential therapeutic effects of n...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2021-01-01
|
Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2021/6641031 |
id |
doaj-edca8c5c3cac4ad299a7aca944ce8c15 |
---|---|
record_format |
Article |
spelling |
doaj-edca8c5c3cac4ad299a7aca944ce8c152021-08-23T01:32:34ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-42882021-01-01202110.1155/2021/6641031Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty LiverMehdi Zobeiri0Fatemeh Parvizi1Mohammad Reza Kalhori2Mohammad Bagher Majnooni3Mohammad Hosein Farzaei4Mohammad Abdollahi5Internal Medicine DepartmentPharmaceutical Sciences Research CenterRegenerative Medicine Research CenterPharmaceutical Sciences Research CenterPharmaceutical Sciences Research CenterToxicology and Diseases GroupThe increasing prevalence of nonalcoholic fatty liver disease (NAFLD) as multifactorial chronic liver disease and the lack of a specific treatment have begun a new era in its treatment using gene expression changes and microRNAs. This study aimed to investigate the potential therapeutic effects of natural compounds in NAFLD by regulating miRNA expression. MicroRNAs play essential roles in regulating the cell’s biological processes, such as apoptosis, migration, lipid metabolism, insulin resistance, and adipocyte differentiation, by controlling the posttranscriptional gene expression level. The impact of current NAFLD pharmacological management, including drug and biological therapies, is uncertain. In this context, various dietary fruits or medicinal herbal sources have received worldwide attention versus NAFLD development. Natural ingredients such as berberine, lychee pulp, grape seed, and rosemary possess protective and therapeutic effects against NAFLD by modifying the gene’s expression and noncoding RNAs, especially miRNAs.http://dx.doi.org/10.1155/2021/6641031 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehdi Zobeiri Fatemeh Parvizi Mohammad Reza Kalhori Mohammad Bagher Majnooni Mohammad Hosein Farzaei Mohammad Abdollahi |
spellingShingle |
Mehdi Zobeiri Fatemeh Parvizi Mohammad Reza Kalhori Mohammad Bagher Majnooni Mohammad Hosein Farzaei Mohammad Abdollahi Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver Evidence-Based Complementary and Alternative Medicine |
author_facet |
Mehdi Zobeiri Fatemeh Parvizi Mohammad Reza Kalhori Mohammad Bagher Majnooni Mohammad Hosein Farzaei Mohammad Abdollahi |
author_sort |
Mehdi Zobeiri |
title |
Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver |
title_short |
Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver |
title_full |
Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver |
title_fullStr |
Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver |
title_full_unstemmed |
Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver |
title_sort |
targeting mirna by natural products: a novel therapeutic approach for nonalcoholic fatty liver |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-4288 |
publishDate |
2021-01-01 |
description |
The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) as multifactorial chronic liver disease and the lack of a specific treatment have begun a new era in its treatment using gene expression changes and microRNAs. This study aimed to investigate the potential therapeutic effects of natural compounds in NAFLD by regulating miRNA expression. MicroRNAs play essential roles in regulating the cell’s biological processes, such as apoptosis, migration, lipid metabolism, insulin resistance, and adipocyte differentiation, by controlling the posttranscriptional gene expression level. The impact of current NAFLD pharmacological management, including drug and biological therapies, is uncertain. In this context, various dietary fruits or medicinal herbal sources have received worldwide attention versus NAFLD development. Natural ingredients such as berberine, lychee pulp, grape seed, and rosemary possess protective and therapeutic effects against NAFLD by modifying the gene’s expression and noncoding RNAs, especially miRNAs. |
url |
http://dx.doi.org/10.1155/2021/6641031 |
work_keys_str_mv |
AT mehdizobeiri targetingmirnabynaturalproductsanoveltherapeuticapproachfornonalcoholicfattyliver AT fatemehparvizi targetingmirnabynaturalproductsanoveltherapeuticapproachfornonalcoholicfattyliver AT mohammadrezakalhori targetingmirnabynaturalproductsanoveltherapeuticapproachfornonalcoholicfattyliver AT mohammadbaghermajnooni targetingmirnabynaturalproductsanoveltherapeuticapproachfornonalcoholicfattyliver AT mohammadhoseinfarzaei targetingmirnabynaturalproductsanoveltherapeuticapproachfornonalcoholicfattyliver AT mohammadabdollahi targetingmirnabynaturalproductsanoveltherapeuticapproachfornonalcoholicfattyliver |
_version_ |
1721199005622337536 |