Single molecule in vivo analysis of toll-like receptor 9 and CpG DNA interaction.
Toll-like receptor 9 (TLR9) activates the innate immune system in response to oligonucleotides rich in CpG whereas DNA lacking CpG could inhibit its activation. However, the mechanism of how TLR9 interacts with nucleic acid and becomes activated in live cells is not well understood. Here, we report...
Main Authors: | Jiji Chen, Suman Nag, Pierre-Alexandre Vidi, Joseph Irudayaraj |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3070698?pdf=render |
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