Effects of long-term hydrogen intervention on the physiological function of rats
Abstract The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (...
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2020-10-01
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doaj-edd38d7b47c344379904e272a24308dc2020-12-08T09:58:14ZengNature Publishing GroupScientific Reports2045-23222020-10-011011810.1038/s41598-020-75492-wEffects of long-term hydrogen intervention on the physiological function of ratsZhi-ming Xun0Qing-hui Zhao1Yan Zhang2Fang-di Ju3Jin He4Ting-ting Yao5Xiao-kang Zhang6Yang Yi7Sheng-nan Ma8Peng-xiang Zhao9Xiao-yan Jin10Ying-xian Li11Xiao-yang Li12Xue-mei Ma13Fei Xie14College of Life Science and Bio-Engineering, Beijing University of TechnologyCollege of Life Science and Bio-Engineering, Beijing University of TechnologyAffiliated Bayi Brain Hospital, The Seventh Medical Center of PLA General HospitalCollege of Life Science and Bio-Engineering, Beijing University of TechnologyCollege of Life Science and Bio-Engineering, Beijing University of TechnologyCollege of Life Science and Bio-Engineering, Beijing University of TechnologyCollege of Life Science and Bio-Engineering, Beijing University of TechnologyCollege of Life Science and Bio-Engineering, Beijing University of TechnologyCollege of Life Science and Bio-Engineering, Beijing University of TechnologyCollege of Life Science and Bio-Engineering, Beijing University of TechnologyState Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterState Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterBeijing Chao-Yang Hospital Affiliated To Capital Medical UniversityCollege of Life Science and Bio-Engineering, Beijing University of TechnologyCollege of Life Science and Bio-Engineering, Beijing University of TechnologyAbstract The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW intake and HI remains elusive. In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. Among the 13 parameters, the most striking alterations induced by hydrogen treatment were observed in serum myocardial enzymes spectrum. The results also showed that the changes in these parameters occurred at different time points, and the alterations in most of the parameters were much more significant in HI than HRW. The results of this study provides the basic data for the mechanism research and application of molecular hydrogen in the future.https://doi.org/10.1038/s41598-020-75492-w |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhi-ming Xun Qing-hui Zhao Yan Zhang Fang-di Ju Jin He Ting-ting Yao Xiao-kang Zhang Yang Yi Sheng-nan Ma Peng-xiang Zhao Xiao-yan Jin Ying-xian Li Xiao-yang Li Xue-mei Ma Fei Xie |
spellingShingle |
Zhi-ming Xun Qing-hui Zhao Yan Zhang Fang-di Ju Jin He Ting-ting Yao Xiao-kang Zhang Yang Yi Sheng-nan Ma Peng-xiang Zhao Xiao-yan Jin Ying-xian Li Xiao-yang Li Xue-mei Ma Fei Xie Effects of long-term hydrogen intervention on the physiological function of rats Scientific Reports |
author_facet |
Zhi-ming Xun Qing-hui Zhao Yan Zhang Fang-di Ju Jin He Ting-ting Yao Xiao-kang Zhang Yang Yi Sheng-nan Ma Peng-xiang Zhao Xiao-yan Jin Ying-xian Li Xiao-yang Li Xue-mei Ma Fei Xie |
author_sort |
Zhi-ming Xun |
title |
Effects of long-term hydrogen intervention on the physiological function of rats |
title_short |
Effects of long-term hydrogen intervention on the physiological function of rats |
title_full |
Effects of long-term hydrogen intervention on the physiological function of rats |
title_fullStr |
Effects of long-term hydrogen intervention on the physiological function of rats |
title_full_unstemmed |
Effects of long-term hydrogen intervention on the physiological function of rats |
title_sort |
effects of long-term hydrogen intervention on the physiological function of rats |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-10-01 |
description |
Abstract The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW intake and HI remains elusive. In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. Among the 13 parameters, the most striking alterations induced by hydrogen treatment were observed in serum myocardial enzymes spectrum. The results also showed that the changes in these parameters occurred at different time points, and the alterations in most of the parameters were much more significant in HI than HRW. The results of this study provides the basic data for the mechanism research and application of molecular hydrogen in the future. |
url |
https://doi.org/10.1038/s41598-020-75492-w |
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