Prenatally programmed hypertension: role of maternal diabetes
Epidemiological and experimental studies have led to the hypothesis of the fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. Maternal diabetes subjects the fetus to an adverse environment that has been demonstrated to r...
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Associação Brasileira de Divulgação Científica
2011-09-01
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900011 |
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doaj-edd6235713704a30b2425b3d79f7f5402020-11-24T20:43:00ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2011-09-01449899904Prenatally programmed hypertension: role of maternal diabetesG.N. GomesF.Z. GilEpidemiological and experimental studies have led to the hypothesis of the fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. Maternal diabetes subjects the fetus to an adverse environment that has been demonstrated to result in metabolic, cardiovascular and renal impairment in the offspring. The growing amount of obesity in young females in developed and some developing countries should contribute to increasing the incidence of diabetes among pregnant women. In this review, we discuss how renal and extrarenal mechanisms participate in the genesis of hypertension induced by a diabetic status during fetal development.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900011HypertensionMaternal diabetesRenal impairmentSodium retention |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
G.N. Gomes F.Z. Gil |
spellingShingle |
G.N. Gomes F.Z. Gil Prenatally programmed hypertension: role of maternal diabetes Brazilian Journal of Medical and Biological Research Hypertension Maternal diabetes Renal impairment Sodium retention |
author_facet |
G.N. Gomes F.Z. Gil |
author_sort |
G.N. Gomes |
title |
Prenatally programmed hypertension: role of maternal diabetes |
title_short |
Prenatally programmed hypertension: role of maternal diabetes |
title_full |
Prenatally programmed hypertension: role of maternal diabetes |
title_fullStr |
Prenatally programmed hypertension: role of maternal diabetes |
title_full_unstemmed |
Prenatally programmed hypertension: role of maternal diabetes |
title_sort |
prenatally programmed hypertension: role of maternal diabetes |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 1414-431X |
publishDate |
2011-09-01 |
description |
Epidemiological and experimental studies have led to the hypothesis of the fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. Maternal diabetes subjects the fetus to an adverse environment that has been demonstrated to result in metabolic, cardiovascular and renal impairment in the offspring. The growing amount of obesity in young females in developed and some developing countries should contribute to increasing the incidence of diabetes among pregnant women. In this review, we discuss how renal and extrarenal mechanisms participate in the genesis of hypertension induced by a diabetic status during fetal development. |
topic |
Hypertension Maternal diabetes Renal impairment Sodium retention |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900011 |
work_keys_str_mv |
AT gngomes prenatallyprogrammedhypertensionroleofmaternaldiabetes AT fzgil prenatallyprogrammedhypertensionroleofmaternaldiabetes |
_version_ |
1716820965148590080 |