Aging alters the epigenetic asymmetry of HSC division.

Aging alters the epigenetic asymmetry of HSC division.

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control protein 42 (Cdc42). Here we demonstrate-using a compre...

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Bibliographic Details
Main Authors: M Carolina Florian, Markus Klose, Mehmet Sacma, Jelena Jablanovic, Luke Knudson, Kalpana J Nattamai, Gina Marka, Angelika Vollmer, Karin Soller, Vadim Sakk, Nina Cabezas-Wallscheid, Yi Zheng, Medhanie A Mulaw, Ingmar Glauche, Hartmut Geiger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2003389

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