Spot Protein/Creatinine Ratio in Preeclampsia as an Alternative for 24-Hour Urine Protein
Background: Proteinuria is a major component of preeclampsia. Urine protein measurement after 24-hour urine collection is the traditional standard method for the detection of proteinuria. It is time-consuming. As an alternative, random spot sampling for a urine protein to creatinine (P/C) ratio has...
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doaj-edd99ddd56124897bc861df10395832b2020-11-24T22:27:21ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312015-03-01321515510.5152/balkanmedj.2015.15447Spot Protein/Creatinine Ratio in Preeclampsia as an Alternative for 24-Hour Urine ProteinOya Demirci0Pınar Kumru1Arzu Arınkan2Cem Ardıç3Resul Arısoy4Elif Tozkır5Bülent Tandoğan6Habibe Ayvacı7Ahmet S. Tuğrul8Department of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, TurkeyDepartment of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, TurkeyDepartment of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, TurkeyDepartment of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, TurkeyDepartment of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, TurkeyDepartment of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, TurkeyDepartment of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, TurkeyDepartment of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, TurkeyDepartment of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, TurkeyBackground: Proteinuria is a major component of preeclampsia. Urine protein measurement after 24-hour urine collection is the traditional standard method for the detection of proteinuria. It is time-consuming. As an alternative, random spot sampling for a urine protein to creatinine (P/C) ratio has been investigated. Aims: The aim of the study was to determine the diagnostic accuracy of the protein to creatinine ratio (P/C) compared with 24-hour urine collection for the detection of remarkable proteinuria and to evaluate the P/C ratio for different proteinuria ranges in patients with preeclampsia. Study Design: Case-control study. Methods: Two hundred and eleven pregnant women who met the criteria of preeclampsia comprised the study group and fifty three pregnant women were taken as the control group. Spot urine specimens for measuring P/C ratio were obtained taken immediately before 24-hour urine collection. The correlation between the P/C ratio in the spot urine samples and urinary protein excretion in the 24-hour collections was examined using the Spearman correlation test. Results: It was found a good positive correlation between the P/C ratio and 24-hour protein excretion, with a correlation coefficient (r) of 0.758. The best cut-off which gave the maximum area under the curve was 0.45 for 300 mg, 0.9 for 1000 mg, 1.16 for 2000 mg, 1.49 for 3000 mg, 2.28 for 4000 mg and 2.63 for 5000 mg per 24h. A P/C ratio above 0.9 strongly predicts significant proteinuria for more than 1 gram (AUC 0.97, 95% CI: 0.94-0.99 and sensitivity, specificity, positive and negative predictive value of 91%, 95.4%, 95.2%, and 91.2%, respectively). Conclusion: The P/C ratio can be used as a screening test as a good predictor for remarkable proteinuria. The P/C ratio seems to be highly predictive for diagnosis to detect proteinuria over one gram and it could be used as a rapid alternative test in preeclamptic patients not to delay implementation treatment.http://balkanmedicaljournal.org/text.php?lang=en&id=241Preeclampsiaproteinuriaurine protein-creatinine ratio |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Oya Demirci Pınar Kumru Arzu Arınkan Cem Ardıç Resul Arısoy Elif Tozkır Bülent Tandoğan Habibe Ayvacı Ahmet S. Tuğrul |
spellingShingle |
Oya Demirci Pınar Kumru Arzu Arınkan Cem Ardıç Resul Arısoy Elif Tozkır Bülent Tandoğan Habibe Ayvacı Ahmet S. Tuğrul Spot Protein/Creatinine Ratio in Preeclampsia as an Alternative for 24-Hour Urine Protein Balkan Medical Journal Preeclampsia proteinuria urine protein-creatinine ratio |
author_facet |
Oya Demirci Pınar Kumru Arzu Arınkan Cem Ardıç Resul Arısoy Elif Tozkır Bülent Tandoğan Habibe Ayvacı Ahmet S. Tuğrul |
author_sort |
Oya Demirci |
title |
Spot Protein/Creatinine Ratio in Preeclampsia as an Alternative for 24-Hour Urine Protein |
title_short |
Spot Protein/Creatinine Ratio in Preeclampsia as an Alternative for 24-Hour Urine Protein |
title_full |
Spot Protein/Creatinine Ratio in Preeclampsia as an Alternative for 24-Hour Urine Protein |
title_fullStr |
Spot Protein/Creatinine Ratio in Preeclampsia as an Alternative for 24-Hour Urine Protein |
title_full_unstemmed |
Spot Protein/Creatinine Ratio in Preeclampsia as an Alternative for 24-Hour Urine Protein |
title_sort |
spot protein/creatinine ratio in preeclampsia as an alternative for 24-hour urine protein |
publisher |
Galenos Publishing House |
series |
Balkan Medical Journal |
issn |
2146-3123 2146-3131 |
publishDate |
2015-03-01 |
description |
Background: Proteinuria is a major component of preeclampsia. Urine protein measurement after 24-hour urine collection is the traditional standard method for the detection of proteinuria. It is time-consuming. As an alternative, random spot sampling for a urine protein to creatinine (P/C) ratio has been investigated.
Aims: The aim of the study was to determine the diagnostic accuracy of the protein to creatinine ratio (P/C) compared with 24-hour urine collection for the detection of remarkable proteinuria and to evaluate the P/C ratio for different proteinuria ranges in patients with preeclampsia.
Study Design: Case-control study.
Methods: Two hundred and eleven pregnant women who met the criteria of preeclampsia comprised the study group and fifty three pregnant women were taken as the control group. Spot urine specimens for measuring P/C ratio were obtained taken immediately before 24-hour urine collection. The correlation between the P/C ratio in the spot urine samples and urinary protein excretion in the 24-hour collections was examined using the Spearman correlation test.
Results: It was found a good positive correlation between the P/C ratio and 24-hour protein excretion, with a correlation coefficient (r) of 0.758. The best cut-off which gave the maximum area under the curve was 0.45 for 300 mg, 0.9 for 1000 mg, 1.16 for 2000 mg, 1.49 for 3000 mg, 2.28 for 4000 mg and 2.63 for 5000 mg per 24h. A P/C ratio above 0.9 strongly predicts significant proteinuria for more than 1 gram (AUC 0.97, 95% CI: 0.94-0.99 and sensitivity, specificity, positive and negative predictive value of 91%, 95.4%, 95.2%, and 91.2%, respectively).
Conclusion: The P/C ratio can be used as a screening test as a good predictor for remarkable proteinuria. The P/C ratio seems to be highly predictive for diagnosis to detect proteinuria over one gram and it could be used as a rapid alternative test in preeclamptic patients not to delay implementation treatment. |
topic |
Preeclampsia proteinuria urine protein-creatinine ratio |
url |
http://balkanmedicaljournal.org/text.php?lang=en&id=241 |
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