In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums
Chewing gums may be particularly effective means for delivering and maintaining bioactive molecules, included in the gum formulation, able to have an anti-cariogenic effect. The purposes of this study were: to develop novel chewing gums containing quercetin (Qt); to evaluate their release using in v...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-08-01
|
Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/21/8/1008 |
id |
doaj-edf957b7dd0949f1bc12faa4f747866e |
---|---|
record_format |
Article |
spelling |
doaj-edf957b7dd0949f1bc12faa4f747866e2020-11-25T00:45:27ZengMDPI AGMolecules1420-30492016-08-01218100810.3390/molecules21081008molecules21081008In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing GumsGianmaria Fabrizio Ferrazzano0Tiziana Cantile1Marco Coda2Brunella Alcidi3Giancarla Sangianantoni4Aniello Ingenito5Michele Di Stasio6Maria Grazia Volpe7Department of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyNutrition Science Institute, National Council of Researches, Via Roma 64, Avellino 83100, ItalyNutrition Science Institute, National Council of Researches, Via Roma 64, Avellino 83100, ItalyChewing gums may be particularly effective means for delivering and maintaining bioactive molecules, included in the gum formulation, able to have an anti-cariogenic effect. The purposes of this study were: to develop novel chewing gums containing quercetin (Qt); to evaluate their release using in vivo trial; finally, to test their in vivo antibacterial effect against oral Streptococcus mutans strains. A preliminary study was performed to produce new gums, enriched with the polyphenol quercetin. Then, a first in vivo experimental study was assessed to test the percentages of Qt released in the saliva of young volunteers. Moreover, a second clinical trial was performed to analyze the antibacterial capability of these enriched chewing gums against S. mutans strains after 14 days of daily consumption. The release analysis showed that a more effective release of Qt occurs in the first minutes of chewing, and it does not change saliva pH values. Moreover, Qt included in gums demonstrates an effective antibacterial activity, showing a reduction of the concentration of S. mutans strains in saliva samples, especially after 7 days. Qt included in experimental chewing gums could be efficiently released into the oral cavity and could promote an effective anti-caries concentration in volunteer’s saliva, without changing salivary pH values.http://www.mdpi.com/1420-3049/21/8/1008cariescaries preventionpolyphenolsquercetinchewing gumsrelease kinetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gianmaria Fabrizio Ferrazzano Tiziana Cantile Marco Coda Brunella Alcidi Giancarla Sangianantoni Aniello Ingenito Michele Di Stasio Maria Grazia Volpe |
spellingShingle |
Gianmaria Fabrizio Ferrazzano Tiziana Cantile Marco Coda Brunella Alcidi Giancarla Sangianantoni Aniello Ingenito Michele Di Stasio Maria Grazia Volpe In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums Molecules caries caries prevention polyphenols quercetin chewing gums release kinetics |
author_facet |
Gianmaria Fabrizio Ferrazzano Tiziana Cantile Marco Coda Brunella Alcidi Giancarla Sangianantoni Aniello Ingenito Michele Di Stasio Maria Grazia Volpe |
author_sort |
Gianmaria Fabrizio Ferrazzano |
title |
In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums |
title_short |
In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums |
title_full |
In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums |
title_fullStr |
In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums |
title_full_unstemmed |
In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums |
title_sort |
in vivo release kinetics and antibacterial activity of novel polyphenols-enriched chewing gums |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2016-08-01 |
description |
Chewing gums may be particularly effective means for delivering and maintaining bioactive molecules, included in the gum formulation, able to have an anti-cariogenic effect. The purposes of this study were: to develop novel chewing gums containing quercetin (Qt); to evaluate their release using in vivo trial; finally, to test their in vivo antibacterial effect against oral Streptococcus mutans strains. A preliminary study was performed to produce new gums, enriched with the polyphenol quercetin. Then, a first in vivo experimental study was assessed to test the percentages of Qt released in the saliva of young volunteers. Moreover, a second clinical trial was performed to analyze the antibacterial capability of these enriched chewing gums against S. mutans strains after 14 days of daily consumption. The release analysis showed that a more effective release of Qt occurs in the first minutes of chewing, and it does not change saliva pH values. Moreover, Qt included in gums demonstrates an effective antibacterial activity, showing a reduction of the concentration of S. mutans strains in saliva samples, especially after 7 days. Qt included in experimental chewing gums could be efficiently released into the oral cavity and could promote an effective anti-caries concentration in volunteer’s saliva, without changing salivary pH values. |
topic |
caries caries prevention polyphenols quercetin chewing gums release kinetics |
url |
http://www.mdpi.com/1420-3049/21/8/1008 |
work_keys_str_mv |
AT gianmariafabrizioferrazzano invivoreleasekineticsandantibacterialactivityofnovelpolyphenolsenrichedchewinggums AT tizianacantile invivoreleasekineticsandantibacterialactivityofnovelpolyphenolsenrichedchewinggums AT marcocoda invivoreleasekineticsandantibacterialactivityofnovelpolyphenolsenrichedchewinggums AT brunellaalcidi invivoreleasekineticsandantibacterialactivityofnovelpolyphenolsenrichedchewinggums AT giancarlasangianantoni invivoreleasekineticsandantibacterialactivityofnovelpolyphenolsenrichedchewinggums AT anielloingenito invivoreleasekineticsandantibacterialactivityofnovelpolyphenolsenrichedchewinggums AT micheledistasio invivoreleasekineticsandantibacterialactivityofnovelpolyphenolsenrichedchewinggums AT mariagraziavolpe invivoreleasekineticsandantibacterialactivityofnovelpolyphenolsenrichedchewinggums |
_version_ |
1725270038012755968 |