Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity
There is currently some understanding of the mechanisms that underpin the interactions between circadian rhythmicity and immunity, metabolism and immune response, and circadian rhythmicity and metabolism. In addition, a wealth of studies have led to the conclusion that the commensal microbiota (main...
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doaj-edfe68ef870e4cc3be341c027b775b1b2020-11-25T00:29:24ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-02-01810.3389/fcell.2020.00051510576Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and ImmunityBruno A. Aguilar-López0María Maximina Bertha Moreno-Altamirano1Hazel M. Dockrell2Michael R. Duchen3Francisco Javier Sánchez-García4Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, MexicoLaboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, MexicoDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United KingdomDepartment of Cell and Developmental Biology, University College London, London, United KingdomLaboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, MexicoThere is currently some understanding of the mechanisms that underpin the interactions between circadian rhythmicity and immunity, metabolism and immune response, and circadian rhythmicity and metabolism. In addition, a wealth of studies have led to the conclusion that the commensal microbiota (mainly bacteria) within the intestine contributes to host homeostasis by regulating circadian rhythmicity, metabolism, and the immune system. Experimental studies on how these four biological domains interact with each other have mainly focused on any two of those domains at a time and only occasionally on three. However, a systematic analysis of how these four domains concurrently interact with each other seems to be missing. We have analyzed current evidence that signposts a role for mitochondria as a key hub that supports and integrates activity across all four domains, circadian clocks, metabolic pathways, the intestinal microbiota, and the immune system, coordinating their integration and crosstalk. This work will hopefully provide a new perspective for both hypothesis-building and more systematic experimental approaches.https://www.frontiersin.org/article/10.3389/fcell.2020.00051/fullmitochondriacircadian rhythmicitymetabolismintestinal microbiotaimmune system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bruno A. Aguilar-López María Maximina Bertha Moreno-Altamirano Hazel M. Dockrell Michael R. Duchen Francisco Javier Sánchez-García |
spellingShingle |
Bruno A. Aguilar-López María Maximina Bertha Moreno-Altamirano Hazel M. Dockrell Michael R. Duchen Francisco Javier Sánchez-García Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity Frontiers in Cell and Developmental Biology mitochondria circadian rhythmicity metabolism intestinal microbiota immune system |
author_facet |
Bruno A. Aguilar-López María Maximina Bertha Moreno-Altamirano Hazel M. Dockrell Michael R. Duchen Francisco Javier Sánchez-García |
author_sort |
Bruno A. Aguilar-López |
title |
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity |
title_short |
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity |
title_full |
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity |
title_fullStr |
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity |
title_full_unstemmed |
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity |
title_sort |
mitochondria: an integrative hub coordinating circadian rhythms, metabolism, the microbiome, and immunity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-02-01 |
description |
There is currently some understanding of the mechanisms that underpin the interactions between circadian rhythmicity and immunity, metabolism and immune response, and circadian rhythmicity and metabolism. In addition, a wealth of studies have led to the conclusion that the commensal microbiota (mainly bacteria) within the intestine contributes to host homeostasis by regulating circadian rhythmicity, metabolism, and the immune system. Experimental studies on how these four biological domains interact with each other have mainly focused on any two of those domains at a time and only occasionally on three. However, a systematic analysis of how these four domains concurrently interact with each other seems to be missing. We have analyzed current evidence that signposts a role for mitochondria as a key hub that supports and integrates activity across all four domains, circadian clocks, metabolic pathways, the intestinal microbiota, and the immune system, coordinating their integration and crosstalk. This work will hopefully provide a new perspective for both hypothesis-building and more systematic experimental approaches. |
topic |
mitochondria circadian rhythmicity metabolism intestinal microbiota immune system |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00051/full |
work_keys_str_mv |
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