Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects
Understanding the role of visceral fat accumulation in the occurrence and progression of metabolic syndrome is of considerable interest. In order to understand the difference between visceral tissue biology of healthy and unhealthy obese individuals, we have used microarray profiling to compare geno...
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Wolters Kluwer Medknow Publications
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doaj-ee187a5701e045ada85ba40dcba9eb752020-11-24T23:54:36ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002013-01-0117344645010.4103/2230-8210.111639Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjectsSandeep Kumar MathurPriyanka JainPrashant MathurPoonam PunjabiAtima AgarwalAbhay SharmaUnderstanding the role of visceral fat accumulation in the occurrence and progression of metabolic syndrome is of considerable interest. In order to understand the difference between visceral tissue biology of healthy and unhealthy obese individuals, we have used microarray profiling to compare genome-wide expression differences between visceral adipose tissue biopsies obtained from obese diabetics, and those from age and body mass index (BMI) matched normal glucose tolerance subjects. Whereas genes upregulated in diabetics showed enrichment of natural killer cell mediated cytotoxicity, the downregulated genes showed enrichment of biosynthesis of unsaturated fatty acids. Given the known inhibitory effect of unsaturated fatty acids on inflammation and natural killer cell number or activity, our results suggest that visceral inflammation resulting from decreased levels of unsaturated fatty acids may underlie progression of diabetes in obese individuals.http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=3;spage=446;epage=450;aulast=MathurDiabetesmicroarraytranscriptional analysisvisceral adipose tissue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sandeep Kumar Mathur Priyanka Jain Prashant Mathur Poonam Punjabi Atima Agarwal Abhay Sharma |
spellingShingle |
Sandeep Kumar Mathur Priyanka Jain Prashant Mathur Poonam Punjabi Atima Agarwal Abhay Sharma Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects Indian Journal of Endocrinology and Metabolism Diabetes microarray transcriptional analysis visceral adipose tissue |
author_facet |
Sandeep Kumar Mathur Priyanka Jain Prashant Mathur Poonam Punjabi Atima Agarwal Abhay Sharma |
author_sort |
Sandeep Kumar Mathur |
title |
Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects |
title_short |
Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects |
title_full |
Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects |
title_fullStr |
Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects |
title_full_unstemmed |
Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects |
title_sort |
transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Endocrinology and Metabolism |
issn |
2230-8210 2230-9500 |
publishDate |
2013-01-01 |
description |
Understanding the role of visceral fat accumulation in the occurrence and progression of metabolic syndrome is of considerable interest. In order to understand the difference between visceral tissue biology of healthy and unhealthy obese individuals, we have used microarray profiling to compare genome-wide expression differences between visceral adipose tissue biopsies obtained from obese diabetics, and those from age and body mass index (BMI) matched normal glucose tolerance subjects. Whereas genes upregulated in diabetics showed enrichment of natural killer cell mediated cytotoxicity, the downregulated genes showed enrichment of biosynthesis of unsaturated fatty acids. Given the known inhibitory effect of unsaturated fatty acids on inflammation and natural killer cell number or activity, our results suggest that visceral inflammation resulting from decreased levels of unsaturated fatty acids may underlie progression of diabetes in obese individuals. |
topic |
Diabetes microarray transcriptional analysis visceral adipose tissue |
url |
http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=3;spage=446;epage=450;aulast=Mathur |
work_keys_str_mv |
AT sandeepkumarmathur transcriptomicanalysisofvisceraladiposefromhealthyanddiabeticobesesubjects AT priyankajain transcriptomicanalysisofvisceraladiposefromhealthyanddiabeticobesesubjects AT prashantmathur transcriptomicanalysisofvisceraladiposefromhealthyanddiabeticobesesubjects AT poonampunjabi transcriptomicanalysisofvisceraladiposefromhealthyanddiabeticobesesubjects AT atimaagarwal transcriptomicanalysisofvisceraladiposefromhealthyanddiabeticobesesubjects AT abhaysharma transcriptomicanalysisofvisceraladiposefromhealthyanddiabeticobesesubjects |
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