The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem?
<p>Abstract</p> <p>There is a plethora of published cancer biomarkers but the reality is that very few, if any, new circulating cancer biomarkers have entered the clinic in the last 30 years. I here try to explain this apparent oxymoron by classifying circulating cancer biomarkers...
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2012-08-01
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| Series: | BMC Medicine |
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| Online Access: | http://www.biomedcentral.com/1741-7015/10/87 |
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doaj-ee1981b5c7b74eedb7a8178f0241736e2020-11-24T21:53:01ZengBMCBMC Medicine1741-70152012-08-011018710.1186/1741-7015-10-87The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem?Diamandis Eleftherios P<p>Abstract</p> <p>There is a plethora of published cancer biomarkers but the reality is that very few, if any, new circulating cancer biomarkers have entered the clinic in the last 30 years. I here try to explain this apparent oxymoron by classifying circulating cancer biomarkers into three categories: fraudulent reports (rare); true discoveries of biomarkers, that then fail to meet the demands of the clinic; and false discoveries, which represent artifactual biomarkers. I further provide examples of combinations of some known cancer biomarkers that can perform well in niche clinical applications, despite individually being not useful.</p> http://www.biomedcentral.com/1741-7015/10/87biomarker failuresbiomarker validationcancer biomarkersfalse discoveryimproved biomarkersproteomics |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Diamandis Eleftherios P |
| spellingShingle |
Diamandis Eleftherios P The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? BMC Medicine biomarker failures biomarker validation cancer biomarkers false discovery improved biomarkers proteomics |
| author_facet |
Diamandis Eleftherios P |
| author_sort |
Diamandis Eleftherios P |
| title |
The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? |
| title_short |
The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? |
| title_full |
The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? |
| title_fullStr |
The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? |
| title_full_unstemmed |
The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? |
| title_sort |
failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? |
| publisher |
BMC |
| series |
BMC Medicine |
| issn |
1741-7015 |
| publishDate |
2012-08-01 |
| description |
<p>Abstract</p> <p>There is a plethora of published cancer biomarkers but the reality is that very few, if any, new circulating cancer biomarkers have entered the clinic in the last 30 years. I here try to explain this apparent oxymoron by classifying circulating cancer biomarkers into three categories: fraudulent reports (rare); true discoveries of biomarkers, that then fail to meet the demands of the clinic; and false discoveries, which represent artifactual biomarkers. I further provide examples of combinations of some known cancer biomarkers that can perform well in niche clinical applications, despite individually being not useful.</p> |
| topic |
biomarker failures biomarker validation cancer biomarkers false discovery improved biomarkers proteomics |
| url |
http://www.biomedcentral.com/1741-7015/10/87 |
| work_keys_str_mv |
AT diamandiseleftheriosp thefailureofproteincancerbiomarkerstoreachtheclinicwhyandwhatcanbedonetoaddresstheproblem AT diamandiseleftheriosp failureofproteincancerbiomarkerstoreachtheclinicwhyandwhatcanbedonetoaddresstheproblem |
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