Kinetic, Structural, and Mutational Analysis of Acyl-CoA Carboxylase From Thermobifida fusca YX

Kinetic, Structural, and Mutational Analysis of Acyl-CoA Carboxylase From Thermobifida fusca YX

Acyl-CoA carboxylases (AcCCase) are biotin-dependent enzymes that are capable of carboxylating more than one short chain acyl-CoA substrate. We have conducted structural and kinetic analyses of such an AcCCase from Thermobifida fusca YX, which exhibits promiscuity in carboxylating acetyl-CoA, propio...

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Bibliographic Details
Main Authors: Kiran-Kumar Shivaiah, Bryon Upton, Basil J. Nikolau
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
acyl-CoA
biotin-dependent carboxylases
Thermobifida fusca YX
site-directed mutagenesis
enzyme kinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.615614/full

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