Protein disulfide isomerase-mediated S-nitrosylation facilitates surface expression of P2X7 receptor following status epilepticus

Protein disulfide isomerase-mediated S-nitrosylation facilitates surface expression of P2X7 receptor following status epilepticus

Abstract Background P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel playing important roles in a variety of physiological functions, including inflammation, and apoptotic or necrotic cell death. An extracellular domain has ten cysteine residues forming five intrasubunit disulfide...

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Bibliographic Details
Main Authors: Duk-Shin Lee, Ji-Eun Kim
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Apoptosis
Astrocyte
L-NAME
Microglia
NF-κB
Nitric oxide
Online Access:https://doi.org/10.1186/s12974-020-02058-y

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