Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol
Indonesia has biodiversity potential to be developed as medicinal plants, such as basil leaves (Ocimum sanctum L.). Basil was reported to have a very high antioxidant activity in vitro. The aim of this study was to determine the effect of basil leaves (Ocimum sanctum L.) infusion to liver based Asp...
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Indonesian Society for Cancer Chemoprevention
2016-06-01
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doaj-ee23f2601b4446928483b0ccfa2992272020-11-24T23:15:16ZengIndonesian Society for Cancer ChemopreventionISCC (Indonesian Journal of Cancer Chemoprevention)2088-01972355-89892016-06-0172687310.14499/indonesianjcanchemoprev7iss2pp68-73107Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by ParacetamolNi Nyoman Yuliani0Jefrin Sambara1Maria Hilaria2Harlinda Harlinda3Department of Pharmacy, Polytechnic of Health, KupangDepartment of Pharmacy, Polytechnic of Health, KupangDepartment of Pharmacy, Polytechnic of Health, KupangDepartment of Pharmacy, Polytechnic of Health, KupangIndonesia has biodiversity potential to be developed as medicinal plants, such as basil leaves (Ocimum sanctum L.). Basil was reported to have a very high antioxidant activity in vitro. The aim of this study was to determine the effect of basil leaves (Ocimum sanctum L.) infusion to liver based Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) value in each dose. 18 rats were divided into 6 groups., control group, negative control group treated with CMC Na 0.5%, positive control group treated with Curcuma 3.6 mg / 200gBB, groups of 4-6 consecutive given a 80 mg dose infusion basil / 200 gBB, 160 mg / 200 gBB, 320 mg / 200 gBB for 8 consecutive days, on the day of the 4th and 8th all treatment groups induced by toxic doses of paracetamol (500 mg / 200 gBB) except the normal control group 1, The research data in the form of enzyme activity of AST and ALT were analyzed using parametric and nonparametric ANOVA, and Friedman test with the level of trust then followed by SNK test and Bnj test. The statistical test result with a 95% of level of trust that shown basil infuse with a dose of 80mg / 200gBB, 160mg / 200gBB, 320mg / 200gBB have hepatoprotective effects in rats induced by paracetamol 500mg / 200gBB. Based on the result of changes in average levels of AST on the fourth day and the eighth day of the three treatment infusion, infusion at a dose of 160 mg / 200gBB most effectively reduce average levels of AST and a group that has the average AST closest to the control group is positive, but infusion at a dose of 320mg / 200gBB the group that has the closest average ALT positive control group. Keywords : hepatoprotective, Ocimum sanctum L, Paracetamolhttps://ijcc.chemoprev.org/index.php/ijcc/article/view/106 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ni Nyoman Yuliani Jefrin Sambara Maria Hilaria Harlinda Harlinda |
spellingShingle |
Ni Nyoman Yuliani Jefrin Sambara Maria Hilaria Harlinda Harlinda Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol ISCC (Indonesian Journal of Cancer Chemoprevention) |
author_facet |
Ni Nyoman Yuliani Jefrin Sambara Maria Hilaria Harlinda Harlinda |
author_sort |
Ni Nyoman Yuliani |
title |
Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol |
title_short |
Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol |
title_full |
Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol |
title_fullStr |
Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol |
title_full_unstemmed |
Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol |
title_sort |
effect of basil leaves (ocimum sanctum l.) infusion as hepatoprotective agent induced by paracetamol |
publisher |
Indonesian Society for Cancer Chemoprevention |
series |
ISCC (Indonesian Journal of Cancer Chemoprevention) |
issn |
2088-0197 2355-8989 |
publishDate |
2016-06-01 |
description |
Indonesia has biodiversity potential to be developed as medicinal plants, such as basil leaves (Ocimum sanctum L.). Basil was reported to have a very high antioxidant activity in vitro. The aim of this study was to determine the effect of basil leaves (Ocimum sanctum L.) infusion to liver based Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) value in each dose. 18 rats were divided into 6 groups., control group, negative control group treated with CMC Na 0.5%, positive control group treated with Curcuma 3.6 mg / 200gBB, groups of 4-6 consecutive given a 80 mg dose infusion basil / 200 gBB, 160 mg / 200 gBB, 320 mg / 200 gBB for 8 consecutive days, on the day of the 4th and 8th all treatment groups induced by toxic doses of paracetamol (500 mg / 200 gBB) except the normal control group 1, The research data in the form of enzyme activity of AST and ALT were analyzed using parametric and nonparametric ANOVA, and Friedman test with the level of trust then followed by SNK test and Bnj test. The statistical test result with a 95% of level of trust that shown basil infuse with a dose of 80mg / 200gBB, 160mg / 200gBB, 320mg / 200gBB have hepatoprotective effects in rats induced by paracetamol 500mg / 200gBB. Based on the result of changes in average levels of AST on the fourth day and the eighth day of the three treatment infusion, infusion at a dose of 160 mg / 200gBB most effectively reduce average levels of AST and a group that has the average AST closest to the control group is positive, but infusion at a dose of 320mg / 200gBB the group that has the closest average ALT positive control group.
Keywords : hepatoprotective, Ocimum sanctum L, Paracetamol |
url |
https://ijcc.chemoprev.org/index.php/ijcc/article/view/106 |
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AT ninyomanyuliani effectofbasilleavesocimumsanctumlinfusionashepatoprotectiveagentinducedbyparacetamol AT jefrinsambara effectofbasilleavesocimumsanctumlinfusionashepatoprotectiveagentinducedbyparacetamol AT mariahilaria effectofbasilleavesocimumsanctumlinfusionashepatoprotectiveagentinducedbyparacetamol AT harlindaharlinda effectofbasilleavesocimumsanctumlinfusionashepatoprotectiveagentinducedbyparacetamol |
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