Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.
BACKGROUND: Recent data indicate the Signal Transducer and Activator of Transcription 3 (STAT3) pathway is required for VEGF production and angiogenesis in various types of cancers. STAT3 inhibitors have been shown to reduce tumor microvessel density in tumors but a direct anti-angiogenic activity h...
Main Authors: | Hemant K Bid, Duane Oswald, Chenglong Li, Cheryl A London, Jiayuh Lin, Peter J Houghton |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3328460?pdf=render |
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