Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis

Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis

Many drugs are small molecule inhibitors of cell signalling. Through single cell analysis and mathematical modelling here the authors show that cell-to-cell variability diversifies inhibition response into digital and analogue, and that the two translate into distinct long-term functional responses.

Bibliographic Details
Main Authors: Robert M. Vogel, Amir Erez, Grégoire Altan-Bonnet
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12428
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spelling doaj-ee31dd9b59f14c6fb131538cdce61e182021-05-11T10:43:07ZengNature Publishing GroupNature Communications2041-17232016-09-017111010.1038/ncomms12428Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysisRobert M. Vogel0Amir Erez1Grégoire Altan-Bonnet2ImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan Kettering Cancer CenterImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan Kettering Cancer CenterImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan Kettering Cancer CenterMany drugs are small molecule inhibitors of cell signalling. Through single cell analysis and mathematical modelling here the authors show that cell-to-cell variability diversifies inhibition response into digital and analogue, and that the two translate into distinct long-term functional responses.https://doi.org/10.1038/ncomms12428
collection DOAJ
language English
format Article
sources DOAJ
author Robert M. Vogel
Amir Erez
Grégoire Altan-Bonnet
spellingShingle Robert M. Vogel
Amir Erez
Grégoire Altan-Bonnet
Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
Nature Communications
author_facet Robert M. Vogel
Amir Erez
Grégoire Altan-Bonnet
author_sort Robert M. Vogel
title Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_short Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_full Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_fullStr Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_full_unstemmed Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
title_sort dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-09-01
description Many drugs are small molecule inhibitors of cell signalling. Through single cell analysis and mathematical modelling here the authors show that cell-to-cell variability diversifies inhibition response into digital and analogue, and that the two translate into distinct long-term functional responses.
url https://doi.org/10.1038/ncomms12428
work_keys_str_mv AT robertmvogel dichotomyofcellularinhibitionbysmallmoleculeinhibitorsrevealedbysinglecellanalysis
AT amirerez dichotomyofcellularinhibitionbysmallmoleculeinhibitorsrevealedbysinglecellanalysis
AT gregoirealtanbonnet dichotomyofcellularinhibitionbysmallmoleculeinhibitorsrevealedbysinglecellanalysis
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