Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective study
ABSTRACT Importance The clinical characteristics of infectious mononucleosis (IM) in Chinese children have not been evaluated in multicenter studies, and the effectiveness of antiviral treatment are controversial. Objective To investigate the clinical characteristics of Chinese children with IM and...
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Wiley
2021-09-01
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Series: | Pediatric Investigation |
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Online Access: | https://doi.org/10.1002/ped4.12294 |
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doaj-ee35d6686ea947328f2694d2f62cbe75 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu |
spellingShingle |
Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective study Pediatric Investigation Infectious mononucleosis Antiviral Ganciclovir Acyclovir |
author_facet |
Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu |
author_sort |
Huili Hu |
title |
Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective study |
title_short |
Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective study |
title_full |
Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective study |
title_fullStr |
Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective study |
title_full_unstemmed |
Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective study |
title_sort |
clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in china: a multicenter retrospective study |
publisher |
Wiley |
series |
Pediatric Investigation |
issn |
2574-2272 |
publishDate |
2021-09-01 |
description |
ABSTRACT Importance The clinical characteristics of infectious mononucleosis (IM) in Chinese children have not been evaluated in multicenter studies, and the effectiveness of antiviral treatment are controversial. Objective To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients. Methods Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China. The clinical characteristics were compared among four age groups: <3 years, 3–<6 years, 6–<10 years, and ≥10 years. The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir (ACV), ganciclovir (GCV), and no antiviral therapy (i.e., non‐antiviral group). Results In total, 499 patients were analyzed; most patients were 3–<6 years of age. The most common symptoms and signs included fever (100%), lymphadenopathy (98.6%), pharyngitis (86.4%), eyelid edema (76.8%), and snoring (72.9%). There were significant differences in rash, hepatomegaly, and liver dysfunction among the four age groups. Patients aged < 3 years had a lower incidence of liver dysfunction and a higher incidence of rash. Among the 499 patients, 50.1% were treated with GCV, 26.3% were treated with ACV, and 23.6% received no antiviral therapy. Compared with the non‐antiviral group, patients in the ACV and GCV groups had longer durations of fever (P < 0.001). There were no significant differences in the incidences of complications among the three treatment groups. Interpretation The incidence of IM in Chinese children peaked at 3–<6 years of age. Clinical features of IM varied according to age. Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy. The effectiveness of antiviral therapy for IM requires further analysis. |
topic |
Infectious mononucleosis Antiviral Ganciclovir Acyclovir |
url |
https://doi.org/10.1002/ped4.12294 |
work_keys_str_mv |
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doaj-ee35d6686ea947328f2694d2f62cbe752021-09-23T05:24:11ZengWileyPediatric Investigation2574-22722021-09-015318819410.1002/ped4.12294Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective studyHuili Hu0Huiling Deng1Jing Bi2Yi Xu3Shuangjie Li4Yue Xie5Xinrong Sun6Dongmeng Wang7Xufang Li8Wenxian Ouyang9Bing Hu10Yufeng Zhang11He Tang12Chunxiao Fang13Hui Zhang14Lingyun Guo15Chen Wang16Tianyi Wang17Fengxia Yang18Tao Jiang19Zhengde Xie20Gang Liu21Key Laboratory of Major Diseases in Children Ministry of Education Research Unit of Critical Infection in Children Chinese Academy of Medical Science Department of Infectious Diseases Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Infectious Diseases Xi’an Children’s Hospital Xi’an Shaanxi ChinaDepartment of Infectious Diseases Baoding Children’s Hospital Baoding Hebei ChinaGuangzhou Women and Children’s Medical Center Guangzhou Guangdong ChinaHepatology Center Hunan Children’s Hospital Changsha Hunan ChinaKey Laboratory of Major Diseases in Children Ministry of Education Research Unit of Critical Infection in Children Chinese Academy of Medical Science Department of Infectious Diseases Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Infectious Diseases Xi’an Children’s Hospital Xi’an Shaanxi ChinaDepartment of Infectious Diseases Baoding Children’s Hospital Baoding Hebei ChinaGuangzhou Women and Children’s Medical Center Guangzhou Guangdong ChinaHepatology Center Hunan Children’s Hospital Changsha Hunan ChinaKey Laboratory of Major Diseases in Children Ministry of Education Research Unit of Critical Infection in Children Chinese Academy of Medical Science Department of Infectious Diseases Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Infectious Diseases Xi’an Children’s Hospital Xi’an Shaanxi ChinaDepartment of Infectious Diseases Baoding Children’s Hospital Baoding Hebei ChinaGuangzhou Women and Children’s Medical Center Guangzhou Guangdong ChinaHepatology Center Hunan Children’s Hospital Changsha Hunan ChinaKey Laboratory of Major Diseases in Children Ministry of Education Research Unit of Critical Infection in Children Chinese Academy of Medical Science Department of Infectious Diseases Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Infectious Diseases Xi’an Children’s Hospital Xi’an Shaanxi ChinaDepartment of Infectious Diseases Baoding Children’s Hospital Baoding Hebei ChinaGuangzhou Women and Children’s Medical Center Guangzhou Guangdong ChinaHepatology Center Hunan Children’s Hospital Changsha Hunan ChinaBeijing Key Laboratory of Pediatric Respiratory Infectious Diseases Key Laboratory of Major Diseases in Children Ministry of Education National Clinical Research Center for Respiratory Diseases Research Unit of Critical Infection in Children Chinese Academy of Medical Sciences 2019RU016 Laboratory of Infection and Virology Beijing Pediatric Research Institute Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaKey Laboratory of Major Diseases in Children Ministry of Education Research Unit of Critical Infection in Children Chinese Academy of Medical Science Department of Infectious Diseases Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaABSTRACT Importance The clinical characteristics of infectious mononucleosis (IM) in Chinese children have not been evaluated in multicenter studies, and the effectiveness of antiviral treatment are controversial. Objective To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients. Methods Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China. The clinical characteristics were compared among four age groups: <3 years, 3–<6 years, 6–<10 years, and ≥10 years. The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir (ACV), ganciclovir (GCV), and no antiviral therapy (i.e., non‐antiviral group). Results In total, 499 patients were analyzed; most patients were 3–<6 years of age. The most common symptoms and signs included fever (100%), lymphadenopathy (98.6%), pharyngitis (86.4%), eyelid edema (76.8%), and snoring (72.9%). There were significant differences in rash, hepatomegaly, and liver dysfunction among the four age groups. Patients aged < 3 years had a lower incidence of liver dysfunction and a higher incidence of rash. Among the 499 patients, 50.1% were treated with GCV, 26.3% were treated with ACV, and 23.6% received no antiviral therapy. Compared with the non‐antiviral group, patients in the ACV and GCV groups had longer durations of fever (P < 0.001). There were no significant differences in the incidences of complications among the three treatment groups. Interpretation The incidence of IM in Chinese children peaked at 3–<6 years of age. Clinical features of IM varied according to age. Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy. The effectiveness of antiviral therapy for IM requires further analysis.https://doi.org/10.1002/ped4.12294Infectious mononucleosisAntiviralGanciclovirAcyclovir |