New Lignans and Iridoid Glycosides from Dipsacus asper Wall
Six new compounds, including four new lignans, dipsalignan A (1), B–D (3–5), and two new bis-iridoid glycoside dimmers, dipsanosides M (7) and N (8), together with two known compounds (2) and (6), have been isolated from the roots of Dipsacus asper Wall. Their structures were established on the basi...
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MDPI AG
2015-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/2/2165 |
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doaj-ee36087bd3bd4dc798ebf7c6b8a5de0f2020-11-24T22:42:55ZengMDPI AGMolecules1420-30492015-01-012022165217510.3390/molecules20022165molecules20022165New Lignans and Iridoid Glycosides from Dipsacus asper WallXinguang Sun0Guoxu Ma1Dawei Zhang2Wenhua Huang3Gang Ding4Huagang Hu5Guangzhong Tu6Baolin Guo7Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaState Nationalities Affairs Commission and Department of Educational Key Lab of Minority Traditional Medicine, MINZU University of China, Beijing 10081, ChinaBeijing Institute of Microchemistry, Beijing 100091, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaSix new compounds, including four new lignans, dipsalignan A (1), B–D (3–5), and two new bis-iridoid glycoside dimmers, dipsanosides M (7) and N (8), together with two known compounds (2) and (6), have been isolated from the roots of Dipsacus asper Wall. Their structures were established on the basis of spectroscopic data (MS, 1D, 2D NMR, and CD) and chemical methods. All the isolated compounds were tested against human immunodeficiency virus-1 (HIV-1) integrase inhibition activities, and only compounds 1, 2, 7, and 8 displayed weak activities.http://www.mdpi.com/1420-3049/20/2/2165Dipsacus asper Walllignansbis-iridoid glycoside |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xinguang Sun Guoxu Ma Dawei Zhang Wenhua Huang Gang Ding Huagang Hu Guangzhong Tu Baolin Guo |
| spellingShingle |
Xinguang Sun Guoxu Ma Dawei Zhang Wenhua Huang Gang Ding Huagang Hu Guangzhong Tu Baolin Guo New Lignans and Iridoid Glycosides from Dipsacus asper Wall Molecules Dipsacus asper Wall lignans bis-iridoid glycoside |
| author_facet |
Xinguang Sun Guoxu Ma Dawei Zhang Wenhua Huang Gang Ding Huagang Hu Guangzhong Tu Baolin Guo |
| author_sort |
Xinguang Sun |
| title |
New Lignans and Iridoid Glycosides from Dipsacus asper Wall |
| title_short |
New Lignans and Iridoid Glycosides from Dipsacus asper Wall |
| title_full |
New Lignans and Iridoid Glycosides from Dipsacus asper Wall |
| title_fullStr |
New Lignans and Iridoid Glycosides from Dipsacus asper Wall |
| title_full_unstemmed |
New Lignans and Iridoid Glycosides from Dipsacus asper Wall |
| title_sort |
new lignans and iridoid glycosides from dipsacus asper wall |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2015-01-01 |
| description |
Six new compounds, including four new lignans, dipsalignan A (1), B–D (3–5), and two new bis-iridoid glycoside dimmers, dipsanosides M (7) and N (8), together with two known compounds (2) and (6), have been isolated from the roots of Dipsacus asper Wall. Their structures were established on the basis of spectroscopic data (MS, 1D, 2D NMR, and CD) and chemical methods. All the isolated compounds were tested against human immunodeficiency virus-1 (HIV-1) integrase inhibition activities, and only compounds 1, 2, 7, and 8 displayed weak activities. |
| topic |
Dipsacus asper Wall lignans bis-iridoid glycoside |
| url |
http://www.mdpi.com/1420-3049/20/2/2165 |
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