Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximab

Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximab

Key Clinical Message A severe and persistent migrainous headache in a patient with primary Sjøgren's syndrome unresponsive to treatment with immunosuppressive drugs, triptans, opioids, and NSAIDs, responded successfully to intrathecal B‐cell depletion with rituximab. We hypothesize that brain‐r...

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Bibliographic Details
Main Authors: Anne Bolette Tjensvoll, Maria Boge Lauvsnes, Katrine Brekke Norheim, Roald Omdal
Format: Article
Language:English
Published: Wiley 2019-03-01
Series:Clinical Case Reports
Subjects:
B cell depletion in CSF
Headache
Primary Sjögren’s syndrome
Systemic lupus erythematosus
Online Access:https://doi.org/10.1002/ccr3.1987
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spelling doaj-ee44d368d5244938b13ac0f45ff4f4a92020-11-25T00:45:39ZengWileyClinical Case Reports2050-09042019-03-017341641810.1002/ccr3.1987Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximabAnne Bolette Tjensvoll0Maria Boge Lauvsnes1Katrine Brekke Norheim2Roald Omdal3Department of Neurology Stavanger University Hospital Stavanger NorwayDepartment of Internal Medicine Stavanger University Hospital Stavanger NorwayDepartment of Internal Medicine Stavanger University Hospital Stavanger NorwayDepartment of Internal Medicine Stavanger University Hospital Stavanger NorwayKey Clinical Message A severe and persistent migrainous headache in a patient with primary Sjøgren's syndrome unresponsive to treatment with immunosuppressive drugs, triptans, opioids, and NSAIDs, responded successfully to intrathecal B‐cell depletion with rituximab. We hypothesize that brain‐resident autoreactive B cells were involved in headache pathogenesis and were eliminated by this procedure.https://doi.org/10.1002/ccr3.1987B cell depletion in CSFHeadachePrimary Sjögren’s syndromeSystemic lupus erythematosus
collection DOAJ
language English
format Article
sources DOAJ
author Anne Bolette Tjensvoll
Maria Boge Lauvsnes
Katrine Brekke Norheim
Roald Omdal
spellingShingle Anne Bolette Tjensvoll
Maria Boge Lauvsnes
Katrine Brekke Norheim
Roald Omdal
Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximab
Clinical Case Reports
B cell depletion in CSF
Headache
Primary Sjögren’s syndrome
Systemic lupus erythematosus
author_facet Anne Bolette Tjensvoll
Maria Boge Lauvsnes
Katrine Brekke Norheim
Roald Omdal
author_sort Anne Bolette Tjensvoll
title Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximab
title_short Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximab
title_full Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximab
title_fullStr Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximab
title_full_unstemmed Severe headache in primary Sjögren’s syndrome treated with intrathecal rituximab
title_sort severe headache in primary sjögren’s syndrome treated with intrathecal rituximab
publisher Wiley
series Clinical Case Reports
issn 2050-0904
publishDate 2019-03-01
description Key Clinical Message A severe and persistent migrainous headache in a patient with primary Sjøgren's syndrome unresponsive to treatment with immunosuppressive drugs, triptans, opioids, and NSAIDs, responded successfully to intrathecal B‐cell depletion with rituximab. We hypothesize that brain‐resident autoreactive B cells were involved in headache pathogenesis and were eliminated by this procedure.
topic B cell depletion in CSF
Headache
Primary Sjögren’s syndrome
Systemic lupus erythematosus
url https://doi.org/10.1002/ccr3.1987
work_keys_str_mv AT annebolettetjensvoll severeheadacheinprimarysjogrenssyndrometreatedwithintrathecalrituximab
AT mariabogelauvsnes severeheadacheinprimarysjogrenssyndrometreatedwithintrathecalrituximab
AT katrinebrekkenorheim severeheadacheinprimarysjogrenssyndrometreatedwithintrathecalrituximab
AT roaldomdal severeheadacheinprimarysjogrenssyndrometreatedwithintrathecalrituximab
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