Laryngeal <i>Helicobacter pylori</i> Infection and Laryngeal Cancer-Case Series and a Systematic Review
<i>Helicobacter pylori</i> (<i>H. pylori</i>) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal <i>H. pylori</i> infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been r...
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doaj-ee55c19813814a349eac55806374e82f2021-06-01T00:52:55ZengMDPI AGMicroorganisms2076-26072021-05-0191129112910.3390/microorganisms9061129Laryngeal <i>Helicobacter pylori</i> Infection and Laryngeal Cancer-Case Series and a Systematic ReviewLi-Jen Hsin0Hai-Hua Chuang1Mu-Yun Lin2Tuan-Jen Fang3Hsueh-Yu Li4Chun-Ta Liao5Chung-Jan Kang6Tse-Ching Chen7Chung-Guei Huang8Tzu-Chen Yen9Li-Ang Lee10Department of Otorhinolaryngology—Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, TaiwanFaculty of Medicine, Chang Gung University, Taoyuan City 33302, TaiwanFaculty of Medicine, Chang Gung University, Taoyuan City 33302, TaiwanDepartment of Otorhinolaryngology—Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, TaiwanDepartment of Otorhinolaryngology—Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, TaiwanDepartment of Otorhinolaryngology—Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, TaiwanDepartment of Otorhinolaryngology—Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, TaiwanFaculty of Medicine, Chang Gung University, Taoyuan City 33302, TaiwanDepartment of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, TaiwanFaculty of Medicine, Chang Gung University, Taoyuan City 33302, TaiwanDepartment of Otorhinolaryngology—Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan<i>Helicobacter pylori</i> (<i>H. pylori</i>) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal <i>H. pylori</i> infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible association between laryngeal <i>H. pylori</i> infection and laryngeal cancer in Taiwan and perform a systematic review of previous reports in other countries. An analysis of 105 patients with laryngeal lesions found the positive rates of <i>H. pylori</i> DNA (determined by polymerase chain reaction) and antigen (determined by immunohistochemistry) of the laryngeal lesions were relatively low (vocal polyps: 3% and 3%; vocal fold leukoplakia: 0% and 0%; laryngeal cancers: 0% and 2%). Furthermore, <i>H. pylori</i>-associated laryngopharyngeal reflux and the expression of <i>E-cadherin</i> and <i>CD1d</i> (determined by immunohistochemistry) were comparable among the three subgroups. Fifteen studies were involved in the systematic review of the digital literature database, distributed to February 2021. The data of patients with laryngeal cancer and controls showed that the laryngeal <i>H. pylori</i> infection rates were 29.4% and 16.7%, respectively. Although current evidence supported that laryngeal <i>H. pylori</i> infection was associated with laryngeal cancer globally, it might not play a role in the development of laryngeal cancer in Taiwan.https://www.mdpi.com/2076-2607/9/6/1129<i>Helicobacter pylori</i>laryngeal cancerlaryngopharyngeal reflux<i>CD1d</i><i>E-cadherin</i> |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li-Jen Hsin Hai-Hua Chuang Mu-Yun Lin Tuan-Jen Fang Hsueh-Yu Li Chun-Ta Liao Chung-Jan Kang Tse-Ching Chen Chung-Guei Huang Tzu-Chen Yen Li-Ang Lee |
spellingShingle |
Li-Jen Hsin Hai-Hua Chuang Mu-Yun Lin Tuan-Jen Fang Hsueh-Yu Li Chun-Ta Liao Chung-Jan Kang Tse-Ching Chen Chung-Guei Huang Tzu-Chen Yen Li-Ang Lee Laryngeal <i>Helicobacter pylori</i> Infection and Laryngeal Cancer-Case Series and a Systematic Review Microorganisms <i>Helicobacter pylori</i> laryngeal cancer laryngopharyngeal reflux <i>CD1d</i> <i>E-cadherin</i> |
author_facet |
Li-Jen Hsin Hai-Hua Chuang Mu-Yun Lin Tuan-Jen Fang Hsueh-Yu Li Chun-Ta Liao Chung-Jan Kang Tse-Ching Chen Chung-Guei Huang Tzu-Chen Yen Li-Ang Lee |
author_sort |
Li-Jen Hsin |
title |
Laryngeal <i>Helicobacter pylori</i> Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_short |
Laryngeal <i>Helicobacter pylori</i> Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_full |
Laryngeal <i>Helicobacter pylori</i> Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_fullStr |
Laryngeal <i>Helicobacter pylori</i> Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_full_unstemmed |
Laryngeal <i>Helicobacter pylori</i> Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_sort |
laryngeal <i>helicobacter pylori</i> infection and laryngeal cancer-case series and a systematic review |
publisher |
MDPI AG |
series |
Microorganisms |
issn |
2076-2607 |
publishDate |
2021-05-01 |
description |
<i>Helicobacter pylori</i> (<i>H. pylori</i>) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal <i>H. pylori</i> infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible association between laryngeal <i>H. pylori</i> infection and laryngeal cancer in Taiwan and perform a systematic review of previous reports in other countries. An analysis of 105 patients with laryngeal lesions found the positive rates of <i>H. pylori</i> DNA (determined by polymerase chain reaction) and antigen (determined by immunohistochemistry) of the laryngeal lesions were relatively low (vocal polyps: 3% and 3%; vocal fold leukoplakia: 0% and 0%; laryngeal cancers: 0% and 2%). Furthermore, <i>H. pylori</i>-associated laryngopharyngeal reflux and the expression of <i>E-cadherin</i> and <i>CD1d</i> (determined by immunohistochemistry) were comparable among the three subgroups. Fifteen studies were involved in the systematic review of the digital literature database, distributed to February 2021. The data of patients with laryngeal cancer and controls showed that the laryngeal <i>H. pylori</i> infection rates were 29.4% and 16.7%, respectively. Although current evidence supported that laryngeal <i>H. pylori</i> infection was associated with laryngeal cancer globally, it might not play a role in the development of laryngeal cancer in Taiwan. |
topic |
<i>Helicobacter pylori</i> laryngeal cancer laryngopharyngeal reflux <i>CD1d</i> <i>E-cadherin</i> |
url |
https://www.mdpi.com/2076-2607/9/6/1129 |
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