Clinical Trial: Marine Lipid Suppositories as Laxatives

Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extr...

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Main Authors: Orri Thor Ormarsson, Einar Stefansson, Thorsteinn Loftsson, Pall Hegli Moller, Thormodur Geirsson, Einar Stefan Bjornsson, Tomas Jonsson
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Marine Drugs
Subjects:
Online Access:http://www.mdpi.com/1660-3397/10/9/2047
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spelling doaj-ee6ba98423a64ad5a3ab8724a2eefb622020-11-25T02:38:50ZengMDPI AGMarine Drugs1660-33972012-09-011092047205410.3390/md10092047Clinical Trial: Marine Lipid Suppositories as LaxativesOrri Thor OrmarssonEinar StefanssonThorsteinn LoftssonPall Hegli MollerThormodur GeirssonEinar Stefan BjornssonTomas JonssonCod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories. Thirty healthy volunteers were randomized either to a study group administrating 30% FFA suppositories and applying 30% FFA ointment to the perianal region twice per day for two weeks, or to a control group using placebo suppositories and ointment in a double blinded manner. Results: No serious toxic effects or irritation were observed. In the study group 93% felt the urge to defecate after administration of the suppositories as compared to 37% in the control group (P = 0.001). Subsequently 90% in the study group defecated, compared to 33% in the control group (P = 0.001). Conclusion: The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period. The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials.http://www.mdpi.com/1660-3397/10/9/2047suppositoriesointmentlaxativeomega-3 fatty acidclinical trial
collection DOAJ
language English
format Article
sources DOAJ
author Orri Thor Ormarsson
Einar Stefansson
Thorsteinn Loftsson
Pall Hegli Moller
Thormodur Geirsson
Einar Stefan Bjornsson
Tomas Jonsson
spellingShingle Orri Thor Ormarsson
Einar Stefansson
Thorsteinn Loftsson
Pall Hegli Moller
Thormodur Geirsson
Einar Stefan Bjornsson
Tomas Jonsson
Clinical Trial: Marine Lipid Suppositories as Laxatives
Marine Drugs
suppositories
ointment
laxative
omega-3 fatty acid
clinical trial
author_facet Orri Thor Ormarsson
Einar Stefansson
Thorsteinn Loftsson
Pall Hegli Moller
Thormodur Geirsson
Einar Stefan Bjornsson
Tomas Jonsson
author_sort Orri Thor Ormarsson
title Clinical Trial: Marine Lipid Suppositories as Laxatives
title_short Clinical Trial: Marine Lipid Suppositories as Laxatives
title_full Clinical Trial: Marine Lipid Suppositories as Laxatives
title_fullStr Clinical Trial: Marine Lipid Suppositories as Laxatives
title_full_unstemmed Clinical Trial: Marine Lipid Suppositories as Laxatives
title_sort clinical trial: marine lipid suppositories as laxatives
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2012-09-01
description Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories. Thirty healthy volunteers were randomized either to a study group administrating 30% FFA suppositories and applying 30% FFA ointment to the perianal region twice per day for two weeks, or to a control group using placebo suppositories and ointment in a double blinded manner. Results: No serious toxic effects or irritation were observed. In the study group 93% felt the urge to defecate after administration of the suppositories as compared to 37% in the control group (P = 0.001). Subsequently 90% in the study group defecated, compared to 33% in the control group (P = 0.001). Conclusion: The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period. The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials.
topic suppositories
ointment
laxative
omega-3 fatty acid
clinical trial
url http://www.mdpi.com/1660-3397/10/9/2047
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