Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway

Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway

Increasing lines of evidence identified that dexmedetomidine (DEX) exerted protective effects against sepsis-stimulated acute lung injury via anti-inflammation, anti-oxidation and anti-apoptosis. However, the mechanisms remain unclear. Herein, we investigated whether DEX afforded lung protection by...

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Bibliographic Details
Main Authors: Jia Shi, Tianxi Yu, Kai Song, Shihan Du, Simeng He, Xinxin Hu, Xiangyun Li, Haibo Li, Shuan Dong, Yuan Zhang, Zilei Xie, Cui Li, Jianbo Yu
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Redox Biology
Subjects:
Dexmedetomidine
Endotoxin
Acute lung injury
Mitochondrial dynamics
Hypoxia-inducible factor 1
Heme oxygenase-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001026

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