In vivo field recordings effectively monitor the mouse cortex and hippocampus under isoflurane anesthesia

• Main Authors: Yi-qing Yin, Li-fang Wang, Chao Chen, Teng Gao, Zi-fang Zhao, Cheng-hui Li
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2016-01-01
• Series: Neural Regeneration Research
• Subjects: nerve regeneration; neurons; isoflurane; patch clamp; cell membrane; synaptic response; inhalational anesthesia; electrophysiology
• Online Access: http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=12;spage=1951;epage=1955;aulast=Yin
• ISSN: 1673-5374

Isoflurane is a widely used inhaled anesthetic in the clinical setting. However, the mechanism underlying its effect on consciousness is under discussion. Therefore, we investigated the effect of isoflurane on the hippocampus and cortex using an in vivo field recording approach. Our results showed that 1.3%, 0.8%, and 0.4% isoflurane exerted an inhibitory influence on the mouse hippocampus and cortex. Further, high frequency bands in the cortex and hippocampus showed greater suppression with increasing isoflurane concentration. Our findings suggest that in vivo field recordings can monitor the effect of isoflurane anesthesia on the mouse cortex and hippocampus.