Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain
Abstract The aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected...
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2021-02-01
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doaj-ee747fc8f94b4c69b730816d1dda7ae42021-02-07T12:36:52ZengNature Publishing GroupScientific Reports2045-23222021-02-011111810.1038/s41598-021-82548-yIncidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, SpainInés Urrutia0Alicia Martín-Nieto1Rosa Martínez2J Oriol Casanovas-Marsal3Anibal Aguayo4Juan del Olmo5Eunate Arana6Elsa Fernandez-Rubio7Luis Castaño8Sonia Gaztambide9The Diabetes Epidemiology GroupBiocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHUBiocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHUBiocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHUBiocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHUBiocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHUClinical Chemistry Laboratory, Cruces University Hospital, OsakidetzaBiocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHUBiocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHUBiocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHUBiocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHUAbstract The aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected from all over the Basque Country and were invited to answer a medical questionnaire, followed by a physical examination and an oral glucose tolerance test. In the reassessment, the same variables were collected and the resulting cohort comprised 517 individuals of whom 43 had diabetes at baseline. The cumulative incidence of diabetes was 4.64% in 7 years and the raw incidence rate was 6.56 cases/1000 person-years (95%CI: 4.11–9.93). Among the incident cases, 59% were undiagnosed. The most strongly associated markers by univariate analyses were age > 60 years, dyslipidaemia, prediabetes and insulin resistance. We also found association with hypertension, obesity, family history of diabetes and low education level. Multivariate analysis adjusted for age and sex showed that a set of risk factors assessed together (dyslipidaemia, waist-to-hip-ratio and family history of diabetes) had great predictive value (AUC-ROC = 0.899, 95%CI: 0.846–0.953, p = 0.942), which suggests the need for early intervention before the onset of prediabetes.https://doi.org/10.1038/s41598-021-82548-y |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Inés Urrutia Alicia Martín-Nieto Rosa Martínez J Oriol Casanovas-Marsal Anibal Aguayo Juan del Olmo Eunate Arana Elsa Fernandez-Rubio Luis Castaño Sonia Gaztambide The Diabetes Epidemiology Group |
spellingShingle |
Inés Urrutia Alicia Martín-Nieto Rosa Martínez J Oriol Casanovas-Marsal Anibal Aguayo Juan del Olmo Eunate Arana Elsa Fernandez-Rubio Luis Castaño Sonia Gaztambide The Diabetes Epidemiology Group Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain Scientific Reports |
author_facet |
Inés Urrutia Alicia Martín-Nieto Rosa Martínez J Oriol Casanovas-Marsal Anibal Aguayo Juan del Olmo Eunate Arana Elsa Fernandez-Rubio Luis Castaño Sonia Gaztambide The Diabetes Epidemiology Group |
author_sort |
Inés Urrutia |
title |
Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain |
title_short |
Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain |
title_full |
Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain |
title_fullStr |
Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain |
title_full_unstemmed |
Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain |
title_sort |
incidence of diabetes mellitus and associated risk factors in the adult population of the basque country, spain |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-02-01 |
description |
Abstract The aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected from all over the Basque Country and were invited to answer a medical questionnaire, followed by a physical examination and an oral glucose tolerance test. In the reassessment, the same variables were collected and the resulting cohort comprised 517 individuals of whom 43 had diabetes at baseline. The cumulative incidence of diabetes was 4.64% in 7 years and the raw incidence rate was 6.56 cases/1000 person-years (95%CI: 4.11–9.93). Among the incident cases, 59% were undiagnosed. The most strongly associated markers by univariate analyses were age > 60 years, dyslipidaemia, prediabetes and insulin resistance. We also found association with hypertension, obesity, family history of diabetes and low education level. Multivariate analysis adjusted for age and sex showed that a set of risk factors assessed together (dyslipidaemia, waist-to-hip-ratio and family history of diabetes) had great predictive value (AUC-ROC = 0.899, 95%CI: 0.846–0.953, p = 0.942), which suggests the need for early intervention before the onset of prediabetes. |
url |
https://doi.org/10.1038/s41598-021-82548-y |
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