Personalizing Radiation Treatment Delivery in the Management of Breast Cancer

Long-term data establishes the efficacy of radiotherapy in the adjuvant management of breast cancer. New dose and fractionation schemas have evolved and are available, each with unique risks and rewards. Current efforts are ongoing to tailor radiotherapy to the unique biology of breast cancer. In th...

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Main Authors:	Kamran A. Ahmed, G. Daniel Grass, Amber G. Orman, Casey Liveringhouse, Michael E. Montejo, Hatem H. Soliman, Heather S. Han, Brian J. Czerniecki, Javier F. Torres-Roca, Roberto Diaz
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	International Journal of Breast Cancer
Online Access:	http://dx.doi.org/10.1155/2018/6729802

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spelling	doaj-ee765a08ba8745459fbdace64229f26e2020-11-24T21:39:02ZengHindawi LimitedInternational Journal of Breast Cancer2090-31702090-31892018-01-01201810.1155/2018/67298026729802Personalizing Radiation Treatment Delivery in the Management of Breast CancerKamran A. Ahmed0G. Daniel Grass1Amber G. Orman2Casey Liveringhouse3Michael E. Montejo4Hatem H. Soliman5Heather S. Han6Brian J. Czerniecki7Javier F. Torres-Roca8Roberto Diaz9Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USADepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USADepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USAUniversity of South Florida College of Medicine, Tampa, FL 33612, USADepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USADepartment of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USADepartment of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USADepartment of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USADepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USADepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USALong-term data establishes the efficacy of radiotherapy in the adjuvant management of breast cancer. New dose and fractionation schemas have evolved and are available, each with unique risks and rewards. Current efforts are ongoing to tailor radiotherapy to the unique biology of breast cancer. In this review, we discuss our efforts to personalize radiotherapy dosing using genomic data and the implications for future clinical trials. We also explore immune mechanisms that may contribute to a tumor’s unique radiation sensitivity or resistance.http://dx.doi.org/10.1155/2018/6729802
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kamran A. Ahmed G. Daniel Grass Amber G. Orman Casey Liveringhouse Michael E. Montejo Hatem H. Soliman Heather S. Han Brian J. Czerniecki Javier F. Torres-Roca Roberto Diaz
spellingShingle	Kamran A. Ahmed G. Daniel Grass Amber G. Orman Casey Liveringhouse Michael E. Montejo Hatem H. Soliman Heather S. Han Brian J. Czerniecki Javier F. Torres-Roca Roberto Diaz Personalizing Radiation Treatment Delivery in the Management of Breast Cancer International Journal of Breast Cancer
author_facet	Kamran A. Ahmed G. Daniel Grass Amber G. Orman Casey Liveringhouse Michael E. Montejo Hatem H. Soliman Heather S. Han Brian J. Czerniecki Javier F. Torres-Roca Roberto Diaz
author_sort	Kamran A. Ahmed
title	Personalizing Radiation Treatment Delivery in the Management of Breast Cancer
title_short	Personalizing Radiation Treatment Delivery in the Management of Breast Cancer
title_full	Personalizing Radiation Treatment Delivery in the Management of Breast Cancer
title_fullStr	Personalizing Radiation Treatment Delivery in the Management of Breast Cancer
title_full_unstemmed	Personalizing Radiation Treatment Delivery in the Management of Breast Cancer
title_sort	personalizing radiation treatment delivery in the management of breast cancer
publisher	Hindawi Limited
series	International Journal of Breast Cancer
issn	2090-3170 2090-3189
publishDate	2018-01-01
description	Long-term data establishes the efficacy of radiotherapy in the adjuvant management of breast cancer. New dose and fractionation schemas have evolved and are available, each with unique risks and rewards. Current efforts are ongoing to tailor radiotherapy to the unique biology of breast cancer. In this review, we discuss our efforts to personalize radiotherapy dosing using genomic data and the implications for future clinical trials. We also explore immune mechanisms that may contribute to a tumor’s unique radiation sensitivity or resistance.
url	http://dx.doi.org/10.1155/2018/6729802
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Personalizing Radiation Treatment Delivery in the Management of Breast Cancer

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