Dendritic cells in atherosclerotic inflammation: The complexity of functions and the peculiarities of pathophysiological effects
Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells t...
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doaj-ee7d497a419a44b1b2a19a031a0f16e32020-11-24T20:54:22ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-05-01510.3389/fphys.2014.0019686590Dendritic cells in atherosclerotic inflammation: The complexity of functions and the peculiarities of pathophysiological effectsYuri V Bobryshev0University of New South Wales and University of Western SydneyAtherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells that further propagate atherosclerotic inflammation. Regulatory T cells (Tregs) can suppress proinflammatory function of mature DCs. In contrast, immature DCs are able to induce Tregs and prevent differentiation of naïve T cells to proinflammatory effector T cells by initiating apoptosis and anergy in naïve T cells. Indeed, immature DCs showed tolerogenic and anti-inflammatory properties. Thus, DCs play a double role in atherosclerosis: mature DCs are proatherogenic while immature DCs appear to be anti-atherogenic. Tolerogenic and anti-inflammatory capacity of immature DCs can be therefore utilized for the development of new immunotherapeutic strategies against atherosclerosis.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00196/fullArteriesAtherosclerosisDendritic CellsInflammationatherogenesisImmune reactions |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuri V Bobryshev |
spellingShingle |
Yuri V Bobryshev Dendritic cells in atherosclerotic inflammation: The complexity of functions and the peculiarities of pathophysiological effects Frontiers in Physiology Arteries Atherosclerosis Dendritic Cells Inflammation atherogenesis Immune reactions |
author_facet |
Yuri V Bobryshev |
author_sort |
Yuri V Bobryshev |
title |
Dendritic cells in atherosclerotic inflammation: The complexity of functions and the peculiarities of pathophysiological effects |
title_short |
Dendritic cells in atherosclerotic inflammation: The complexity of functions and the peculiarities of pathophysiological effects |
title_full |
Dendritic cells in atherosclerotic inflammation: The complexity of functions and the peculiarities of pathophysiological effects |
title_fullStr |
Dendritic cells in atherosclerotic inflammation: The complexity of functions and the peculiarities of pathophysiological effects |
title_full_unstemmed |
Dendritic cells in atherosclerotic inflammation: The complexity of functions and the peculiarities of pathophysiological effects |
title_sort |
dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2014-05-01 |
description |
Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells that further propagate atherosclerotic inflammation. Regulatory T cells (Tregs) can suppress proinflammatory function of mature DCs. In contrast, immature DCs are able to induce Tregs and prevent differentiation of naïve T cells to proinflammatory effector T cells by initiating apoptosis and anergy in naïve T cells. Indeed, immature DCs showed tolerogenic and anti-inflammatory properties. Thus, DCs play a double role in atherosclerosis: mature DCs are proatherogenic while immature DCs appear to be anti-atherogenic. Tolerogenic and anti-inflammatory capacity of immature DCs can be therefore utilized for the development of new immunotherapeutic strategies against atherosclerosis. |
topic |
Arteries Atherosclerosis Dendritic Cells Inflammation atherogenesis Immune reactions |
url |
http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00196/full |
work_keys_str_mv |
AT yurivbobryshev dendriticcellsinatheroscleroticinflammationthecomplexityoffunctionsandthepeculiaritiesofpathophysiologicaleffects |
_version_ |
1716794739461718016 |