Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV

Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV

The human immunodeficiency virus type 1 (HIV-1) protein Vpu is encoded exclusively by HIV-1 and related simian immunodeficiency viruses (SIVs). The transmembrane domain of the protein has dual functions: it counteracts the human restriction factor tetherin and forms a cation channel. Since these two...

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Bibliographic Details
Main Authors: Timo Greiner, Sebastian Bolduan, Brigitte Hertel, Christine Groß, Kay Hamacher, Ulrich Schubert, Anna Moroni, Gerhard Thiel
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Viruses
Subjects:
Vpu channel function
viroporin
virus channel evolution
Vpu transmembrane domain
Online Access:http://www.mdpi.com/1999-4915/8/12/325

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