Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome
Abstract Introduction Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease (AD) and its associated dementia, warranting the development of strategies to improve early detection when prevention is possible. Methods Using a broad battery of neuropsychological assessm...
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doaj-ee807874e26d4e8d95b14100f009a8132021-04-15T14:35:47ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292020-01-01121n/an/a10.1002/dad2.12044Promising outcome measures of early Alzheimer's dementia in adults with Down syndromeSharon J Krinsky‐McHale0Warren B. Zigman1Joseph H. Lee2Nicole Schupf3Deborah Pang4Tracy Listwan5Cynthia Kovacs6Wayne Silverman7New York State Institute for Basic Research in Developmental Disabilities Staten Island New York USANew York State Institute for Basic Research in Developmental Disabilities Staten Island New York USADepartment of Neurology College of Physicians and Surgeons Columbia University Sergievsky Center/Taub Institute New York New York USADepartment of Neurology College of Physicians and Surgeons Columbia University Sergievsky Center/Taub Institute New York New York USANew York State Institute for Basic Research in Developmental Disabilities Staten Island New York USANew York State Institute for Basic Research in Developmental Disabilities Staten Island New York USANew York State Institute for Basic Research in Developmental Disabilities Staten Island New York USADepartment of Epidemiology School of Public Health Columbia University New York New York USAAbstract Introduction Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease (AD) and its associated dementia, warranting the development of strategies to improve early detection when prevention is possible. Methods Using a broad battery of neuropsychological assessments, informant interviews, and clinical record review, we evaluated the psychometrics of measures in a large sample of 561 adults with DS. We tracked longitudinal stability or decline in functioning in a subsample of 269 participants over a period of 3 years, all initially without indications of clinically significant aging‐related decline. Results Results identified an array of objective measures that demonstrated sensitivity in distinguishing individuals with incident “mild cognitive impairment” (MCI‐DS) as well as subsequent declines occurring with incident dementia. Discussion Several instruments showed clear promise for use as outcome measures for future clinical trials and for informing diagnosis of individuals suspected of experiencing early signs and symptoms of a progressive dementia process.https://doi.org/10.1002/dad2.12044agingAlzheimer's diseaseDown syndromemild cognitive impairment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sharon J Krinsky‐McHale Warren B. Zigman Joseph H. Lee Nicole Schupf Deborah Pang Tracy Listwan Cynthia Kovacs Wayne Silverman |
spellingShingle |
Sharon J Krinsky‐McHale Warren B. Zigman Joseph H. Lee Nicole Schupf Deborah Pang Tracy Listwan Cynthia Kovacs Wayne Silverman Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring aging Alzheimer's disease Down syndrome mild cognitive impairment |
author_facet |
Sharon J Krinsky‐McHale Warren B. Zigman Joseph H. Lee Nicole Schupf Deborah Pang Tracy Listwan Cynthia Kovacs Wayne Silverman |
author_sort |
Sharon J Krinsky‐McHale |
title |
Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome |
title_short |
Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome |
title_full |
Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome |
title_fullStr |
Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome |
title_full_unstemmed |
Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome |
title_sort |
promising outcome measures of early alzheimer's dementia in adults with down syndrome |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2020-01-01 |
description |
Abstract Introduction Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease (AD) and its associated dementia, warranting the development of strategies to improve early detection when prevention is possible. Methods Using a broad battery of neuropsychological assessments, informant interviews, and clinical record review, we evaluated the psychometrics of measures in a large sample of 561 adults with DS. We tracked longitudinal stability or decline in functioning in a subsample of 269 participants over a period of 3 years, all initially without indications of clinically significant aging‐related decline. Results Results identified an array of objective measures that demonstrated sensitivity in distinguishing individuals with incident “mild cognitive impairment” (MCI‐DS) as well as subsequent declines occurring with incident dementia. Discussion Several instruments showed clear promise for use as outcome measures for future clinical trials and for informing diagnosis of individuals suspected of experiencing early signs and symptoms of a progressive dementia process. |
topic |
aging Alzheimer's disease Down syndrome mild cognitive impairment |
url |
https://doi.org/10.1002/dad2.12044 |
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