Modulation of Glutamate Transporter EAAT1 and Inward-Rectifier Potassium Channel K<sub>ir4.1</sub> Expression in Cultured Spinal Cord Astrocytes by Platinum-Based Chemotherapeutics

Modulation of Glutamate Transporter EAAT1 and Inward-Rectifier Potassium Channel K<sub>ir4.1</sub> Expression in Cultured Spinal Cord Astrocytes by Platinum-Based Chemotherapeutics

Platinum-based chemotherapeutics still play an essential role in cancer treatment. Despite their high effectiveness, severe side effects such as chemotherapy-induced neuropathy (CIPN) occur frequently. The pathophysiology of CIPN by platinum-based chemotherapeutics is not fully understood yet, but p...

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Bibliographic Details
Main Authors: Markus Leo, Linda-Isabell Schmitt, Rebecca Steffen, Andrea Kutritz, Christoph Kleinschnitz, Tim Hagenacker
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
chemotherapy-induced neuropathy
spinal cord
astrocytes
cisplatin
oxaliplatin
potassium channel
Online Access:https://www.mdpi.com/1422-0067/22/12/6300

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