Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England

• Main Authors: Clarence C. Tam, Sarah J. O’Brien, Laura C. Rodrigues
• Format: Article
• Language: English
• Published: Centers for Disease Control and Prevention 2006-12-01
• Series: Emerging Infectious Diseases
• Subjects: Guillain-Barré syndrome; Campylobacter; influenza; Mycoplasma pneumoniae; Haemophilus influenzae; cytomegalovirus
• Online Access: https://wwwnc.cdc.gov/eid/article/12/12/05-1032_article
• ISSN: 1080-6040; 1080-6059

Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in polio-free regions. Considerable evidence links Campylobacter infection with GBS, but evidence that implicates other pathogens as triggers remains scarce. We conducted a time-series analysis to investigate short-term correlations between weekly laboratory-confirmed reports of putative triggering pathogens and weekly hospitalizations for GBS in England from 1993 through 2002. We found a positive association between the numbers of reports of laboratory-confirmed influenza A in any given week and GBS hospitalizations in the same week. Different pathogens may trigger GBS in persons of different ages; among those <35 years, numbers of weekly GBS hospitalizations were associated with weekly Campylobacter and Mycoplasma pneumoniae reports, whereas among those >35 years, positive associations were with influenza. Further studies should estimate the relative contribution of different pathogens to GBS incidence, overall and by age group, and determine whether influenza is a real trigger for GBS or a marker for influenza vaccination.