Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England
Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in polio-free regions. Considerable evidence links Campylobacter infection with GBS, but evidence that implicates other pathogens as triggers remains scarce. We conducted a time-series analysis to investigate short-ter...
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doaj-ee8d105158ba403ab002244213c9aed42020-11-24T21:51:02ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592006-12-0112121880188710.3201/eid1212.051032Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, EnglandClarence C. TamSarah J. O’BrienLaura C. RodriguesGuillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in polio-free regions. Considerable evidence links Campylobacter infection with GBS, but evidence that implicates other pathogens as triggers remains scarce. We conducted a time-series analysis to investigate short-term correlations between weekly laboratory-confirmed reports of putative triggering pathogens and weekly hospitalizations for GBS in England from 1993 through 2002. We found a positive association between the numbers of reports of laboratory-confirmed influenza A in any given week and GBS hospitalizations in the same week. Different pathogens may trigger GBS in persons of different ages; among those <35 years, numbers of weekly GBS hospitalizations were associated with weekly Campylobacter and Mycoplasma pneumoniae reports, whereas among those >35 years, positive associations were with influenza. Further studies should estimate the relative contribution of different pathogens to GBS incidence, overall and by age group, and determine whether influenza is a real trigger for GBS or a marker for influenza vaccination.https://wwwnc.cdc.gov/eid/article/12/12/05-1032_articleGuillain-Barré syndromeCampylobacterinfluenzaMycoplasma pneumoniaeHaemophilus influenzaecytomegalovirus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Clarence C. Tam Sarah J. O’Brien Laura C. Rodrigues |
spellingShingle |
Clarence C. Tam Sarah J. O’Brien Laura C. Rodrigues Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England Emerging Infectious Diseases Guillain-Barré syndrome Campylobacter influenza Mycoplasma pneumoniae Haemophilus influenzae cytomegalovirus |
author_facet |
Clarence C. Tam Sarah J. O’Brien Laura C. Rodrigues |
author_sort |
Clarence C. Tam |
title |
Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England |
title_short |
Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England |
title_full |
Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England |
title_fullStr |
Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England |
title_full_unstemmed |
Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England |
title_sort |
influenza, campylobacter and mycoplasma infections, and hospital admissions for guillain-barré syndrome, england |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2006-12-01 |
description |
Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in polio-free regions. Considerable evidence links Campylobacter infection with GBS, but evidence that implicates other pathogens as triggers remains scarce. We conducted a time-series analysis to investigate short-term correlations between weekly laboratory-confirmed reports of putative triggering pathogens and weekly hospitalizations for GBS in England from 1993 through 2002. We found a positive association between the numbers of reports of laboratory-confirmed influenza A in any given week and GBS hospitalizations in the same week. Different pathogens may trigger GBS in persons of different ages; among those <35 years, numbers of weekly GBS hospitalizations were associated with weekly Campylobacter and Mycoplasma pneumoniae reports, whereas among those >35 years, positive associations were with influenza. Further studies should estimate the relative contribution of different pathogens to GBS incidence, overall and by age group, and determine whether influenza is a real trigger for GBS or a marker for influenza vaccination. |
topic |
Guillain-Barré syndrome Campylobacter influenza Mycoplasma pneumoniae Haemophilus influenzae cytomegalovirus |
url |
https://wwwnc.cdc.gov/eid/article/12/12/05-1032_article |
work_keys_str_mv |
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