Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat
Objective: The purpose of the present study was to examine whether Rheum ribes extract prevents cisplatin-induced nephrotoxicity. Materials and Methods: The animals were divided into three groups: Group A considered as control group, group B were treated with cisplatin (3 mg/kg B.W. for 3 alternativ...
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2013-01-01
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doaj-eec03c2388614b93869f7935edb3a1972020-11-24T22:49:02ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74060976-48792013-01-015430931310.4103/0975-7406.120083Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in ratMousa-Al-Reza HadjzadehZiba RajaeiZakieh KeshavarziMohsen Ghasem ShiraziVahedeh ToosiObjective: The purpose of the present study was to examine whether Rheum ribes extract prevents cisplatin-induced nephrotoxicity. Materials and Methods: The animals were divided into three groups: Group A considered as control group, group B were treated with cisplatin (3 mg/kg B.W. for 3 alternative days), and group C further to cisplatin received the aqueous extract of Rheum ribes (150 mg/rat). Results: Blood urea nitrogen (BUN) level increased in group B on days 14 and 42 compared to day 0 ( P < 0.001); it was also increased in group B vs. group A on day 14 ( P < 0.001). Rheum ribes extract decreased the serum BUN level on day 14 compared to group B ( P < 0.001). Serum creatinine level in group B had a similar profile as serum BUN level but Rheum ribes had no effect on blood creatinine level. Serum cholesterol level was increased in group B on days 14 and 42 compared to day 0 ( P < 0.001). Also, cholesterol level was significantly increased in group B when compared to group A on day 14 ( P < 0.001). Rheum ribes decreased the blood cholesterol level on day 42 in comparison to group B ( P < 0.001). Serum glucose level was increased in group B on days 14 and 42 vs. day 0 ( P < 0.001). Also, glucose level was significantly increased in group B when compared to group A on day 42 ( P < 0.001). Rheum ribes increased the serum glucose level on days 14 and 42 compared to day 0 ( P < 0.05). Histology of kidneys exposed to cisplatin showed renal injury, but Rheum ribes had no effect on the kidney architecture. Conclusion: Cisplatin-induced nephrotoxicity was confirmed in our study. Although Rheum ribes had some effects on biochemical parameters; its effect on renal histology in injured kidney was insignificant.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2013;volume=5;issue=4;spage=309;epage=313;aulast=HadjzadehBlood urea nitrogencholesterolcisplatincreatinine Rheum ribes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mousa-Al-Reza Hadjzadeh Ziba Rajaei Zakieh Keshavarzi Mohsen Ghasem Shirazi Vahedeh Toosi |
spellingShingle |
Mousa-Al-Reza Hadjzadeh Ziba Rajaei Zakieh Keshavarzi Mohsen Ghasem Shirazi Vahedeh Toosi Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat Journal of Pharmacy and Bioallied Sciences Blood urea nitrogen cholesterol cisplatin creatinine Rheum ribes |
author_facet |
Mousa-Al-Reza Hadjzadeh Ziba Rajaei Zakieh Keshavarzi Mohsen Ghasem Shirazi Vahedeh Toosi |
author_sort |
Mousa-Al-Reza Hadjzadeh |
title |
Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat |
title_short |
Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat |
title_full |
Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat |
title_fullStr |
Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat |
title_full_unstemmed |
Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat |
title_sort |
effect of aqueous extract of rheum ribes on cisplatin-induced nephrotoxicity in rat |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Pharmacy and Bioallied Sciences |
issn |
0975-7406 0976-4879 |
publishDate |
2013-01-01 |
description |
Objective: The purpose of the present study was to examine whether Rheum ribes extract prevents cisplatin-induced nephrotoxicity. Materials and Methods: The animals were divided into three groups: Group A considered as control group, group B were treated with cisplatin (3 mg/kg B.W. for 3 alternative days), and group C further to cisplatin received the aqueous extract of Rheum ribes (150 mg/rat). Results: Blood urea nitrogen (BUN) level increased in group B on days 14 and 42 compared to day 0 ( P < 0.001); it was also increased in group B vs. group A on day 14 ( P < 0.001). Rheum ribes extract decreased the serum BUN level on day 14 compared to group B ( P < 0.001). Serum creatinine level in group B had a similar profile as serum BUN level but Rheum ribes had no effect on blood creatinine level. Serum cholesterol level was increased in group B on days 14 and 42 compared to day 0 ( P < 0.001). Also, cholesterol level was significantly increased in group B when compared to group A on day 14 ( P < 0.001). Rheum ribes decreased the blood cholesterol level on day 42 in comparison to group B ( P < 0.001). Serum glucose level was increased in group B on days 14 and 42 vs. day 0 ( P < 0.001). Also, glucose level was significantly increased in group B when compared to group A on day 42 ( P < 0.001). Rheum ribes increased the serum glucose level on days 14 and 42 compared to day 0 ( P < 0.05). Histology of kidneys exposed to cisplatin showed renal injury, but Rheum ribes had no effect on the kidney architecture. Conclusion: Cisplatin-induced nephrotoxicity was confirmed in our study. Although Rheum ribes had some effects on biochemical parameters; its effect on renal histology in injured kidney was insignificant. |
topic |
Blood urea nitrogen cholesterol cisplatin creatinine Rheum ribes |
url |
http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2013;volume=5;issue=4;spage=309;epage=313;aulast=Hadjzadeh |
work_keys_str_mv |
AT mousaalrezahadjzadeh effectofaqueousextractofrheumribesoncisplatininducednephrotoxicityinrat AT zibarajaei effectofaqueousextractofrheumribesoncisplatininducednephrotoxicityinrat AT zakiehkeshavarzi effectofaqueousextractofrheumribesoncisplatininducednephrotoxicityinrat AT mohsenghasemshirazi effectofaqueousextractofrheumribesoncisplatininducednephrotoxicityinrat AT vahedehtoosi effectofaqueousextractofrheumribesoncisplatininducednephrotoxicityinrat |
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