Hyposalivation and Poor Dental Health Status Are Potential Correlates of Age-Related Cognitive Decline in Late Midlife in Danish Men
Introduction: Peripheral correlates of age-associated cognitive decline are important tools in the screening for potentially abnormal courses of cognitive aging. Since salivary gland function is controlled by the autonomic and central nervous system, associations between cognitive changes and saliva...
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Frontiers Media S.A.
2018-01-01
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Series: | Frontiers in Aging Neuroscience |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00010/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christiane E. Sørensen Christiane E. Sørensen Naja L. Hansen Naja L. Hansen Erik L. Mortensen Erik L. Mortensen Erik L. Mortensen Martin Lauritzen Martin Lauritzen Martin Lauritzen Merete Osler Merete Osler Merete Osler Anne M. L. Pedersen Anne M. L. Pedersen |
spellingShingle |
Christiane E. Sørensen Christiane E. Sørensen Naja L. Hansen Naja L. Hansen Erik L. Mortensen Erik L. Mortensen Erik L. Mortensen Martin Lauritzen Martin Lauritzen Martin Lauritzen Merete Osler Merete Osler Merete Osler Anne M. L. Pedersen Anne M. L. Pedersen Hyposalivation and Poor Dental Health Status Are Potential Correlates of Age-Related Cognitive Decline in Late Midlife in Danish Men Frontiers in Aging Neuroscience salivary secretion xerostomia DMFs index oral health age-related changes in cognition central autonomic control |
author_facet |
Christiane E. Sørensen Christiane E. Sørensen Naja L. Hansen Naja L. Hansen Erik L. Mortensen Erik L. Mortensen Erik L. Mortensen Martin Lauritzen Martin Lauritzen Martin Lauritzen Merete Osler Merete Osler Merete Osler Anne M. L. Pedersen Anne M. L. Pedersen |
author_sort |
Christiane E. Sørensen |
title |
Hyposalivation and Poor Dental Health Status Are Potential Correlates of Age-Related Cognitive Decline in Late Midlife in Danish Men |
title_short |
Hyposalivation and Poor Dental Health Status Are Potential Correlates of Age-Related Cognitive Decline in Late Midlife in Danish Men |
title_full |
Hyposalivation and Poor Dental Health Status Are Potential Correlates of Age-Related Cognitive Decline in Late Midlife in Danish Men |
title_fullStr |
Hyposalivation and Poor Dental Health Status Are Potential Correlates of Age-Related Cognitive Decline in Late Midlife in Danish Men |
title_full_unstemmed |
Hyposalivation and Poor Dental Health Status Are Potential Correlates of Age-Related Cognitive Decline in Late Midlife in Danish Men |
title_sort |
hyposalivation and poor dental health status are potential correlates of age-related cognitive decline in late midlife in danish men |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2018-01-01 |
description |
Introduction: Peripheral correlates of age-associated cognitive decline are important tools in the screening for potentially abnormal courses of cognitive aging. Since salivary gland function is controlled by the autonomic and central nervous system, associations between cognitive changes and salivary gland hypofunction were tested in two groups of middle-aged men in late midlife, who differed substantially with respect to their midlife performance in verbal intelligence when compared with their performance in young adulthood.Materials and Methods: Participants (n = 193) were recruited from the Danish Metropolit Cohort of men born in 1953. Based on their individual change in performance in two previously administered intelligence tests, they were allocated to one group of positive and one group of negative outliers in midlife cognition scores, indicating no decline versus decline in test performance. All participants underwent a clinical oral examination including assessments of their dental, periodontal, and mucosal conditions. Whole and parotid saliva flow rates were measured, and the number of systemic diseases and medication intake as well as daytime and nocturnal xerostomia were registered.Results: Participants with decline in cognitive test performance in midlife had significantly lower unstimulated whole saliva flow rates, higher prevalence of hyposalivation and daytime xerostomia and a higher caries experience than participants with no decline in midlife performance. Daytime and nocturnal xerostomia were associated with daily intake of medication and alcohol.Discussion: Overall, hyposalivation, xerostomia and poor dental status distinguished a group of men displaying relative decline in cognitive performance from a group of men without evidence of cognitive decline. Thus, hyposalivation and poor dental health status may represent potential correlates of age-related cognitive decline in late midlife, provided that other causes can be excluded. |
topic |
salivary secretion xerostomia DMFs index oral health age-related changes in cognition central autonomic control |
url |
http://journal.frontiersin.org/article/10.3389/fnagi.2018.00010/full |
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doaj-eec86a4cae2a40c7bc4a169c021bece22020-11-24T20:42:48ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-01-011010.3389/fnagi.2018.00010310952Hyposalivation and Poor Dental Health Status Are Potential Correlates of Age-Related Cognitive Decline in Late Midlife in Danish MenChristiane E. Sørensen0Christiane E. Sørensen1Naja L. Hansen2Naja L. Hansen3Erik L. Mortensen4Erik L. Mortensen5Erik L. Mortensen6Martin Lauritzen7Martin Lauritzen8Martin Lauritzen9Merete Osler10Merete Osler11Merete Osler12Anne M. L. Pedersen13Anne M. L. Pedersen14Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkFunctional Imaging Unit, Diagnostic Department, Rigshospitalet-Glostrup, Glostrup, DenmarkCenter for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDanish Aging Research Center, Universities of Aarhus, Southern Denmark and Copenhagen, Odense, DenmarkCenter for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Neurophysiology, Rigshospitalet-Glostrup, Copenhagen, DenmarkDepartment of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDanish Aging Research Center, Universities of Aarhus, Southern Denmark and Copenhagen, Odense, DenmarkResearch Center for Prevention and Health, Rigshospitalet-Glostrup, Copenhagen, DenmarkSection of Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkIntroduction: Peripheral correlates of age-associated cognitive decline are important tools in the screening for potentially abnormal courses of cognitive aging. Since salivary gland function is controlled by the autonomic and central nervous system, associations between cognitive changes and salivary gland hypofunction were tested in two groups of middle-aged men in late midlife, who differed substantially with respect to their midlife performance in verbal intelligence when compared with their performance in young adulthood.Materials and Methods: Participants (n = 193) were recruited from the Danish Metropolit Cohort of men born in 1953. Based on their individual change in performance in two previously administered intelligence tests, they were allocated to one group of positive and one group of negative outliers in midlife cognition scores, indicating no decline versus decline in test performance. All participants underwent a clinical oral examination including assessments of their dental, periodontal, and mucosal conditions. Whole and parotid saliva flow rates were measured, and the number of systemic diseases and medication intake as well as daytime and nocturnal xerostomia were registered.Results: Participants with decline in cognitive test performance in midlife had significantly lower unstimulated whole saliva flow rates, higher prevalence of hyposalivation and daytime xerostomia and a higher caries experience than participants with no decline in midlife performance. Daytime and nocturnal xerostomia were associated with daily intake of medication and alcohol.Discussion: Overall, hyposalivation, xerostomia and poor dental status distinguished a group of men displaying relative decline in cognitive performance from a group of men without evidence of cognitive decline. Thus, hyposalivation and poor dental health status may represent potential correlates of age-related cognitive decline in late midlife, provided that other causes can be excluded.http://journal.frontiersin.org/article/10.3389/fnagi.2018.00010/fullsalivary secretionxerostomiaDMFs indexoral healthage-related changes in cognitioncentral autonomic control |