Brain metabolic alterations herald falls in patients with Parkinson’s disease

Brain metabolic alterations herald falls in patients with Parkinson’s disease

Abstract Pathophysiological understanding of gait and balance disorders in Parkinson’s disease is insufficient and late recognition of fall risk limits efficacious follow‐up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with i...

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Main Authors: Ioannis U. Isaias, Joachim Brumberg, Nicoló G. Pozzi, Chiara Palmisano, Andrea Canessa, Giorgio Marotta, Jens Volkmann, Gianni Pezzoli
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51013
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spelling doaj-eed45dc0d2cc4d129009b9385841e6952021-05-02T22:36:34ZengWileyAnnals of Clinical and Translational Neurology2328-95032020-04-017457958310.1002/acn3.51013Brain metabolic alterations herald falls in patients with Parkinson’s diseaseIoannis U. Isaias0Joachim Brumberg1Nicoló G. Pozzi2Chiara Palmisano3Andrea Canessa4Giorgio Marotta5Jens Volkmann6Gianni Pezzoli7Department of Neurology University Hospital and Julius Maximilian University of Würzburg Würzburg GermanyDepartment of Nuclear Medicine University Hospital Würzburg Würzburg GermanyDepartment of Neurology University Hospital and Julius Maximilian University of Würzburg Würzburg GermanyDepartment of Neurology University Hospital and Julius Maximilian University of Würzburg Würzburg GermanyFondazione Europea di Ricerca Biomedica (FERB Onlus) Cernusco s/N (Milano) ItalyDepartment of Nuclear Medicine Fondazione IRCCS Ca' Granda – Ospedale Maggiore Policlinico Milano ItalyDepartment of Neurology University Hospital and Julius Maximilian University of Würzburg Würzburg GermanyCentro Parkinson ASST G. Pini‐CTO Milano ItalyAbstract Pathophysiological understanding of gait and balance disorders in Parkinson’s disease is insufficient and late recognition of fall risk limits efficacious follow‐up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6–8 months before their first fall episode. Falls in Parkinson’s disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.https://doi.org/10.1002/acn3.51013
collection DOAJ
language English
format Article
sources DOAJ
author Ioannis U. Isaias
Joachim Brumberg
Nicoló G. Pozzi
Chiara Palmisano
Andrea Canessa
Giorgio Marotta
Jens Volkmann
Gianni Pezzoli
spellingShingle Ioannis U. Isaias
Joachim Brumberg
Nicoló G. Pozzi
Chiara Palmisano
Andrea Canessa
Giorgio Marotta
Jens Volkmann
Gianni Pezzoli
Brain metabolic alterations herald falls in patients with Parkinson’s disease
Annals of Clinical and Translational Neurology
author_facet Ioannis U. Isaias
Joachim Brumberg
Nicoló G. Pozzi
Chiara Palmisano
Andrea Canessa
Giorgio Marotta
Jens Volkmann
Gianni Pezzoli
author_sort Ioannis U. Isaias
title Brain metabolic alterations herald falls in patients with Parkinson’s disease
title_short Brain metabolic alterations herald falls in patients with Parkinson’s disease
title_full Brain metabolic alterations herald falls in patients with Parkinson’s disease
title_fullStr Brain metabolic alterations herald falls in patients with Parkinson’s disease
title_full_unstemmed Brain metabolic alterations herald falls in patients with Parkinson’s disease
title_sort brain metabolic alterations herald falls in patients with parkinson’s disease
publisher Wiley
series Annals of Clinical and Translational Neurology
issn 2328-9503
publishDate 2020-04-01
description Abstract Pathophysiological understanding of gait and balance disorders in Parkinson’s disease is insufficient and late recognition of fall risk limits efficacious follow‐up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6–8 months before their first fall episode. Falls in Parkinson’s disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.
url https://doi.org/10.1002/acn3.51013
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AT giorgiomarotta brainmetabolicalterationsheraldfallsinpatientswithparkinsonsdisease
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