Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis
Epidemiological studies have provided ambiguous evidence on the association between vitamin E and esophageal cancer risk. To resolve this controversy, we performed this meta-analysis. The literature was searched by using Excerpta Medica Database (EMBASE), PubMed, the Web of Science, and the Cochrane...
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doaj-eede60d8287940f29f3b283fa9773fe92020-11-25T00:20:59ZengMDPI AGNutrients2072-66432018-06-0110780110.3390/nu10070801nu10070801Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-AnalysisLingling Cui0Li Li1Yalan Tian2Fan Xu3Tianyi Qiao4Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaEpidemiological studies have provided ambiguous evidence on the association between vitamin E and esophageal cancer risk. To resolve this controversy, we performed this meta-analysis. The literature was searched by using Excerpta Medica Database (EMBASE), PubMed, the Web of Science, and the Cochrane Library from the inception to April 2018. A random effect model was utilized to calculate the odds ratio (OR) with the 95% confidence interval (95% CI). Twelve articles reporting 14 studies involving 3013 cases and 11,384 non-cases were included. By comparing the highest category with the lowest category of dietary vitamin E intake, we found that dietary vitamin E intake was inversely related to esophageal cancer risk (OR = 0.47, 95% CI: 0.36–0.60). Subgroup analysis revealed that dietary vitamin E intake had a significantly negative association with both the esophageal squamous cell carcinoma risk (OR = 0.29, 95% CI: 0.18–0.44) and the esophageal adenocarcinoma risk (OR = 0.66, 95% CI: 0.49–0.88). No study significantly affected the findings in the sensitivity analysis. Publication bias was discovered, however, the OR (95% CI) remained unchanged after the trim-and-fill analysis. This meta-analysis showed that the higher dietary vitamin E intake is associated with a lower esophageal cancer risk. However, the association still needs to be upheld by more large-scaled randomized controlled trials and prospective studies.http://www.mdpi.com/2072-6643/10/7/801dietaryvitamin Etocopherolesophageal cancermeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lingling Cui Li Li Yalan Tian Fan Xu Tianyi Qiao |
spellingShingle |
Lingling Cui Li Li Yalan Tian Fan Xu Tianyi Qiao Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis Nutrients dietary vitamin E tocopherol esophageal cancer meta-analysis |
author_facet |
Lingling Cui Li Li Yalan Tian Fan Xu Tianyi Qiao |
author_sort |
Lingling Cui |
title |
Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis |
title_short |
Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis |
title_full |
Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis |
title_fullStr |
Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis |
title_full_unstemmed |
Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis |
title_sort |
association between dietary vitamin e intake and esophageal cancer risk: an updated meta-analysis |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-06-01 |
description |
Epidemiological studies have provided ambiguous evidence on the association between vitamin E and esophageal cancer risk. To resolve this controversy, we performed this meta-analysis. The literature was searched by using Excerpta Medica Database (EMBASE), PubMed, the Web of Science, and the Cochrane Library from the inception to April 2018. A random effect model was utilized to calculate the odds ratio (OR) with the 95% confidence interval (95% CI). Twelve articles reporting 14 studies involving 3013 cases and 11,384 non-cases were included. By comparing the highest category with the lowest category of dietary vitamin E intake, we found that dietary vitamin E intake was inversely related to esophageal cancer risk (OR = 0.47, 95% CI: 0.36–0.60). Subgroup analysis revealed that dietary vitamin E intake had a significantly negative association with both the esophageal squamous cell carcinoma risk (OR = 0.29, 95% CI: 0.18–0.44) and the esophageal adenocarcinoma risk (OR = 0.66, 95% CI: 0.49–0.88). No study significantly affected the findings in the sensitivity analysis. Publication bias was discovered, however, the OR (95% CI) remained unchanged after the trim-and-fill analysis. This meta-analysis showed that the higher dietary vitamin E intake is associated with a lower esophageal cancer risk. However, the association still needs to be upheld by more large-scaled randomized controlled trials and prospective studies. |
topic |
dietary vitamin E tocopherol esophageal cancer meta-analysis |
url |
http://www.mdpi.com/2072-6643/10/7/801 |
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