A meta-analysis of parental smoking and the risk of childhood brain tumors.
OBJECTIVE: Previous studies regarding the association between parental smoking and the risk of childhood brain tumors (CBT) have reported inconsistent results. We performed a meta-analysis to summarize evidence on this association and to quantify the potential dose-response relationship. METHODS: A...
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doaj-eee2cc689d934606ab6282826e9c29f72020-11-25T01:13:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10291010.1371/journal.pone.0102910A meta-analysis of parental smoking and the risk of childhood brain tumors.Yi HuangJianrong HuangHuan LanGuanYan ZhaoChunZhen HuangOBJECTIVE: Previous studies regarding the association between parental smoking and the risk of childhood brain tumors (CBT) have reported inconsistent results. We performed a meta-analysis to summarize evidence on this association and to quantify the potential dose-response relationship. METHODS: A systematic literature search was conducted in the Medline and Embase databases. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Dose-response meta-analysis was also performed for studies that reported categorical risk estimates for a series of smoking exposure levels. RESULTS: A total of 17 studies fulfilled the inclusion criteria. In the meta-analyses, the summary RRs (95% CIs) of CBT for maternal smoking during pregnancy, paternal smoking during pregnancy, maternal smoking before pregnancy, and paternal smoking before pregnancy were 0.96 (0.86-1.07), 1.09 (0.97-1.22), 0.93 (0.85-1.00), and 1.09 (1.00-1.20), respectively. Dose-response meta-analysis also showed no significant association between parental smoking and the risk of CBT. CONCLUSIONS: Findings from our meta-analysis indicate that parental smoking may not be associated with a risk of CBT.http://europepmc.org/articles/PMC4109951?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi Huang Jianrong Huang Huan Lan GuanYan Zhao ChunZhen Huang |
spellingShingle |
Yi Huang Jianrong Huang Huan Lan GuanYan Zhao ChunZhen Huang A meta-analysis of parental smoking and the risk of childhood brain tumors. PLoS ONE |
author_facet |
Yi Huang Jianrong Huang Huan Lan GuanYan Zhao ChunZhen Huang |
author_sort |
Yi Huang |
title |
A meta-analysis of parental smoking and the risk of childhood brain tumors. |
title_short |
A meta-analysis of parental smoking and the risk of childhood brain tumors. |
title_full |
A meta-analysis of parental smoking and the risk of childhood brain tumors. |
title_fullStr |
A meta-analysis of parental smoking and the risk of childhood brain tumors. |
title_full_unstemmed |
A meta-analysis of parental smoking and the risk of childhood brain tumors. |
title_sort |
meta-analysis of parental smoking and the risk of childhood brain tumors. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
OBJECTIVE: Previous studies regarding the association between parental smoking and the risk of childhood brain tumors (CBT) have reported inconsistent results. We performed a meta-analysis to summarize evidence on this association and to quantify the potential dose-response relationship. METHODS: A systematic literature search was conducted in the Medline and Embase databases. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Dose-response meta-analysis was also performed for studies that reported categorical risk estimates for a series of smoking exposure levels. RESULTS: A total of 17 studies fulfilled the inclusion criteria. In the meta-analyses, the summary RRs (95% CIs) of CBT for maternal smoking during pregnancy, paternal smoking during pregnancy, maternal smoking before pregnancy, and paternal smoking before pregnancy were 0.96 (0.86-1.07), 1.09 (0.97-1.22), 0.93 (0.85-1.00), and 1.09 (1.00-1.20), respectively. Dose-response meta-analysis also showed no significant association between parental smoking and the risk of CBT. CONCLUSIONS: Findings from our meta-analysis indicate that parental smoking may not be associated with a risk of CBT. |
url |
http://europepmc.org/articles/PMC4109951?pdf=render |
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