Design and Characterization of a Cell-Penetrating Peptide Derived from the SOX2 Transcription Factor

Design and Characterization of a Cell-Penetrating Peptide Derived from the SOX2 Transcription Factor

SOX2 is an oncogenic transcription factor overexpressed in nearly half of the basal-like triple-negative breast cancers associated with very poor outcomes. Targeting and inhibiting SOX2 is clinically relevant as high SOX2 mRNA levels are positively correlated with decreased overall survival and prog...

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Bibliographic Details
Main Authors: Neha S. Gandhi, Edina Wang, Anabel Sorolla, Yu Jie Kan, Adil Malik, Jyotsna Batra, Kimberly A. Young, Wan Jun Tie, Pilar Blancafort, Ricardo L. Mancera
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
iPep
cell-penetrating peptides
SOX2
homeodomain
molecular dynamics
cellular internalization
Online Access:https://www.mdpi.com/1422-0067/22/17/9354

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