Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

Summary: Malignant rhabdoid tumors (MRTs) represent one of the most aggressive childhood malignancies. No effective treatment options are available, and prognosis is, therefore, dismal. Previous studies have demonstrated that tumor organoids capture the heterogeneity of patient tumors and can be use...

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Main Authors: Camilla Calandrini, Sander R. van Hooff, Irene Paassen, Dilara Ayyildiz, Sepide Derakhshan, M. Emmy M. Dolman, Karin P.S. Langenberg, Marieke van de Ven, Cecilia de Heus, Nalan Liv, Marcel Kool, Ronald R. de Krijger, Godelieve A.M. Tytgat, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Jarno Drost
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
malignant rhabdoid tumors
organoids
drug screening
neddylation
MLN4924
targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010020

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