Production of L-asparaginase by filamentous fungi

Production of L-asparaginase by filamentous fungi

L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii and Aspergillus terreus. The fungi were cultivated in medium containing different nitrogen sources. A. terreus showed the highest L-asparaginase (activity) production level (58 U/L) when cultivated in a 2% prolin...

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Bibliographic Details
Main Authors: Maria Inez de Moura Sarquis, Edna Maria Morais Oliveira, Alberdan Silva Santos, Gisela Lara da Costa
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2004-08-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
filamentous fungi
production of L-asparaginase
Aspergillus tamarii
Aspergillus terreus
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000500005
Description
Summary:L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii and Aspergillus terreus. The fungi were cultivated in medium containing different nitrogen sources. A. terreus showed the highest L-asparaginase (activity) production level (58 U/L) when cultivated in a 2% proline medium. Both fungi presented the lowest level of L-asparaginase production in the presence of glutamine and urea as nitrogen sources. These results suggest that L-asparaginase production by of filamentous fungi is under nitrogen regulation.
ISSN:0074-0276
1678-8060

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