Inhibition of histone deacetylase (HDAC) by 4-phenylbutyrate results in increased junctional conductance between rat corpora smooth muscle cells.

Inhibition of histone deacetylase (HDAC) by 4-phenylbutyrate results in increased junctional conductance between rat corpora smooth muscle cells.

4-phenylbutyrate (4-PB) has been shown to increase the protein content in a number of cells types. One such protein is Connexin43 (Cx43). We show here that 4-phenylbutyrate exposure results in significantly elevated cell to cell coupling, as determined by dual whole cell patch clamp. Incubation wit...

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Bibliographic Details
Main Authors: Hong Zhan Wang, Barbara eRosati, Chris eGordon, Virginijus eValiunas, David eMcKinnon, Ira S Cohen, Peter R Brink
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Pharmacology
Subjects:
protein expression
connexin43
patch clamp
4phenylbutyrate
cell to cell coupling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00009/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00009/full

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