The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer’s Disease: Implications for Treatment

The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer’s Disease: Implications for Treatment

Alzheimer’s disease (AD), a serious neurodegenerative disease, is pathologically characterized by synaptic loss and dysfunction. Synaptic vesicle protein 2A (SV2A) is an indispensable vesicular protein specifically expressed in synapses and can be used as a biomarker for synaptic density. We found t...

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Bibliographic Details
Main Authors: Yanyan Kong, Lin Huang, Weihao Li, Xuanting Liu, Yinping Zhou, Cuiping Liu, Shibo Zhang, Fang Xie, Zhengwei Zhang, Donglang Jiang, Weiyan Zhou, Ruiqing Ni, Chencheng Zhang, Bomin Sun, Jiao Wang, Yihui Guan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Alzheimer’s disease
neurodegeneration
synaptic vesicle protein 2A
Tau
Aβ
PI3K signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.609908/full

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